PROTEOMICS, EarlyView.ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo +2 more
wiley +1 more source
Structural, electronic, intermolecular interaction, reactivity, vibrational spectroscopy, charge transfer, Hirshfeld surface analysis, pharmacological and hydropathy plot on 5-Bromo nicotinic acid - Antiviral study (Hepatitis A, B, and C). [PDF]
Heliyon, 2023 R S +5 more
europepmc +1 more source
Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase
Pest Management Science, EarlyView.The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier +26 more
wiley +1 more source
Novel Mutations in Putative Nicotinic Acid Phosphoribosyltransferases of Mycobacterium tuberculosis and Their Effect on Protein Thermodynamic Properties. [PDF]
Polymers (Basel), 2022 Zhang YJ +6 more
europepmc +1 more source
Small Methods, EarlyView.This review summarizes recent progress in the design and nanoarchitectural control of bimetallic metal–organic frameworks (MOFs) and their applications in quartz crystal microbalance (QCM) sensors for the detection of various gases. It also discusses the underlying sensing mechanisms of bimetallic MOFs and concludes with challenges and future ...
Silvia Chowdhury +4 more
wiley +1 more source
Synthesis, Biological Activity and Molecular Docking Studies of Novel Nicotinic Acid Derivatives. [PDF]
Int J Mol Sci, 2022 Paruch K +5 more
europepmc +1 more source
Absorption of thiamine and nicotinic acid in the rat intestine during fasting and immobilization stress [PDF]
By perfusion of isolated sections of intestine with a solution containing thiamine at a concentration of 3.1 micromole, it was established that thiamine absorption in animals fasted for 72 hours decreased by 28 percent, whereas absorption increased by 12
Khmelevskiy, Y. V., Kirilyuk, O. G.
core +1 more source
Management of Vocal Fold Leukoplakia
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Vocal fold leukoplakia (VFL) is a descriptive term for a white plaque in the true vocal folds (TVF). It is estimated at 10.2 cases per 100,000 males and 2.1 per 100,000 females. The most critical aspect of managing a VLF is achieving an accurate pathological diagnosis, since a white plaque in the TVF can have numerous differential diagnoses ...
Isabela H. Schettini, Thomas L. Carroll
wiley +1 more source
Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners. [PDF]
Molecules, 2021 Frank NA +10 more
europepmc +1 more source
Biological Flora of Britain and Ireland: Cytisus scoparius*
Journal of Ecology, EarlyView.Broom is an attractive and common native plant across Britain, Ireland and most of Europe, and yet it is considered a harmful and invasive weed around the rest of the world. This is aided by broom thriving on poor dry soils, helped by using green stems for photosynthesis and having root nodules to fix nitrogen.
Peter A. Thomas +9 more
wiley +1 more source