Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]
, 2013 Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Kauferstein, Silke +8 more
core +3 more sources
Equilibrium Properties of Mouse-Torpedo Acetylcholine Receptor Hybrids Expressed in Xenopus Oocytes [PDF]
, 1987 This study used messenger RNA encoding each subunit (α, β, γ and δ) of the nicotinic acetylcholine (ACh) receptor from mouse BC3H-1 cells and from Torpedo electric organ.
Davidson, Norman +4 more
core +3 more sources
Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]
, 2013 Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U +3 more
core +3 more sources
Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man1
Journal of Lipid Research, 1981 The mechanisms for the hypolipidemic action of nicotinic acid were examined in 12 patients with hyperlipidemia. Most patients were studied in the hospital on a metabolic ward.
S M Grundy, H Y Mok, L Zech, M Berman
doaj +1 more source
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]
, 2017 Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos +11 more
core +3 more sources
Journal of Biological Chemistry, 1964 6-Hydroxynicotinic acid was demonstrated to be the first intermediate in the degradation of nicotinic acid by a clostridium. In the presence of pyruvate, other intermediates accumulated; two of these were identified, one as 1,4,5,6-tetrahydro-6-oxonicotinic acid, and the other as α-methyleneglutaric acid.
Ira Pastan, Earl R. Stadtman, L. Tsai
openaire +5 more sources
PLoS ONE, 2019 Bordetella bacteria are respiratory pathogens of humans, birds, and livestock. Bordetella pertussis the causative agent of whopping cough remains a significant health issue.
William T Booth +3 more
doaj +1 more source
Chemical Synthesis of a Functional Fluorescent-Tagged α-Bungarotoxin
Toxins, 2022 α-bungarotoxin is a large, 74 amino acid toxin containing five disulphide bridges, initially identified in the venom of Bungarus multicinctus snake. Like most large toxins, chemical synthesis of α-bungarotoxin is challenging, explaining why all previous ...
Oliver Brun +9 more
doaj +1 more source
The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. [PDF]
, 2020 Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Borges, Lucia Soares +3 more
core
Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]
, 2013 Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core +1 more source