Results 31 to 40 of about 5,143,045 (401)

Long-Range Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis [PDF]

, 2009
The functional coupling of residues that are far apart in space is the quintessential property of allosteric proteins. For example, in Cys-loop receptors, the gating of an intrinsic ion channel is allosterically regulated by the binding of small molecule
Dougherty, Dennis A., Frazier, Shawnalea J., Gleitsman, Kristin R., Lester, Henry A., Shanata, Jai A. P.   +4 more
core   +2 more sources

Mixed Oxides as Successful Sorption Materials for Some Active Pharmaceutical Ingredients [PDF]

Chemical and Biochemical Engineering Quarterly, 2020
Mixed oxides based on Mg-Al, Mg-Fe, Zn-Al, and Ni-Mg-Al were prepared, characterized and used as sorption materials for different types of active pharmaceutical ingredients (APIs)– nicotinic acid, salicylic acid, ibuprofen, paracetamol and ascorbic acid.
E. Vrbková, E. Vyskočilová, A. Semrádová, L. Sekerová, L. Červený   +4 more
doaj   +1 more source

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region [PDF]

, 1992
Tris+/Na+ permeability ratios were measured from shifts in the biionic reversal potentials of the macroscopic ACh-induced currents for 3 wild- type (WT), 1 hybrid, 2 subunit-deficient, and 25 mutant nicotinic receptors expressed in Xenopus oocytes.
Cohen, Bruce N., Czyzyk, Linda, Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +4 more
core   +2 more sources

Variation in the Content of Bioactive Compounds in Infusions Prepared from Different Parts of Wild Polish Stinging Nettle (Urtica dioica L.)

Molecules, 2022
Nettle is a common plant that offers many health benefits and is grown all over the world. The content of active compounds in roots, stems, and leaves was determined based on the extraction procedure optimized using the Central Composite Design ...
Magdalena Jeszka-Skowron, Agnieszka Zgoła-Grześkowiak, Robert Frankowski, Tomasz Grześkowiak, Anna Maria Jeszka   +4 more
doaj   +1 more source

Functional characterisation of a nicotinic acetylcholine receptor alpha subunit from the brown dog tick, Rhipicephalus sanguineus [PDF]

, 2014
Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license This work was supported by a Biotechnology and Biological Sciences Research Council (UK) Industrial CASE studentship award (BBSSM200411428) to K.
Alan S. Bowman, Aljamali, Anatriello, Anderson, Andrew K. Jones, Baines, Ball, Bass, Bennett, Bertrand, Bissinger, Blagburn, Blake, Bowman, Breer, Buckingham, Buckingham, Chmelar, David B. Sattelle, Debra J. Woods, Dederer, Dederer, Dermauw, Erdmanis, Gao, Geng, George, Gray, Grbic, Halevi, Halevi, Hedges, Hermsen, Hosie, Hsu, Huang, Inokuma, Jeschke, Jeyaprakash, Jones, Jongejan, Kao, Karim, Kazuhiko Matsuda, Kristin Lees, Kumar, Lansdell, Lansdell, Lansdell, Lees, Lees, Liu, Lupu-Meiri, Marshall, Meinke, Miki Akamatsu, Miller, Mounsey, Nauen, Nene, Perry, Roma, Salgado, Simo, Sonenshine, Song, Tang, Taylor, Turberg, Watson, Woods, Yao, Zheng   +72 more
core   +3 more sources

Molecular adsorption study of nicotine and caffeine on the single-walled carbon nanotube from first principles [PDF]

Solid State Communications, v.167, pp.27 - 30 (2013), 2012
Using first-principles calculations, we investigate the electronic structures and binding properties of nicotine and caffeine adsorbed on single-walled carbon nanotubes to determine whether CNTs are appropriate for filtering or sensing nicotine and caffeine molecules. We find that caffeine adsorbs more strongly than nicotine.
arxiv   +1 more source

A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]

, 2008
Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A., Lummis, Sarah C. R., Lynch, Joseph W., Millen, Kat S., Pless, Stephan A.   +6 more
core   +2 more sources

Single Molecule Transistor based Nanopore for the detection of Nicotine [PDF]

Journal of Applied Physics 116, 244307 (2014), 2015
A nanopore based detection methodology was proposed and investigated for the detection of Nicotine. This technique uses a Single Molecular Transistor (SMT) working as a nanopore operational in the Coulomb Blockade regime. When the Nicotine molecule is pulled through the nanopore area surrounded by the Source(S), Drain(D) and Gate electrodes, the charge
arxiv   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source