Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.
Journal of Clinical Investigation, 1996 We asked whether the well known starvation-induced impairment of glucose-stimulated insulin secretion (GSIS) seen in isolated rat pancreas preparations also applies in vivo.
Daniel T. Stein +8 more
semanticscholar +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Taxonomy of Chemical Bondings: Opportunities and Challenges
Angewandte Chemie, EarlyView.The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi +5 more
wiley +2 more sources
Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
Nature Communications, 2016 Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when ...
Tapan Kumar Nayak +3 more
doaj +1 more source
Contribution of gut microbiomes and their metabolomes to the performance of Dorper and Tan sheep
Frontiers in Microbiology, 2022 BackgroundLivestock is an excellent source of high nutritional value protein for humans; breeding livestock is focused on improving meat productivity and quality. Dorper sheep is a distinguished breed with an excellent growth performance, while Tan sheep
Yuhao Ma +7 more
doaj +1 more source
Chromium (III) complexes and their relationship to the glucose tolerance factor : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 1982 Two forms of the dinicotinate complex Cr(nic)2(H2O)3OH were formed which were yellow and blue, respectively. For the yellow form the nicotinic acid ligands were coordinated via the pyridine ring nitrogen atom but this complex was biologically inactive ...
Cooper, Juan Anton
core
Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]
, 2013 Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U +3 more
core +3 more sources
Photonic Nanomaterials for Wearable Health Solutions
Advanced Materials, EarlyView.This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park +3 more
wiley +1 more source
Electrochemistry of Dihalogenated Nicotonic Acids in Aqueous and Aprotic Media [PDF]
, 1986 The electrochemical reduction of several 2,5- and 5,6- dihalonicotinic acids have been studied in dimethyl sulfoxide as well as in aqueous buffers of different pH.
Battles, Lourie A. +3 more
core +2 more sources
Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus [PDF]
, 2001 Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to ...
Alan Fine +6 more
core +1 more source