Results 161 to 170 of about 41,965 (298)

Agonist-induced hump current production in heterologously-expressed human α4β2-nicotinic acetylcholine receptors [PDF]

, 2008
Qiang Liu, Kewei Yu, Yongchang Chang, Ronald J. Lukas, Jie Wu   +4 more
openalex   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via α3β4-nAChR/PI3K/Akt-Dependent Survivin Upregulation. [PDF]

Oxid Med Cell Longev, 2019
Li P, Yan Y, Shi Y, Cheng B, Zhan Y, Wang Q, Ye Q, Weng Y, Wu T, Wu R.   +9 more
europepmc   +1 more source

Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor

, 2006
Amanda L. Cashin, Michael M. Torrice, Kathryn A. McMenimen, Henry A. Lester, Dennis A. Dougherty   +4 more
openalex   +2 more sources

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations [PDF]

, 2005
Scott B. Hansen, Gerlind Sulzenbacher, Tom Huxford, P. Marchot, Palmer Taylor, Yves Bourne   +5 more
openalex   +1 more source

L‐Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies

Brain and Behavior, Volume 16, Issue 1, January 2026.
L‐quebrachitol (LQL) significantly enhanced the sedative effects of diazepam in thiopental sodium‐induced chicks by reducing sleep latency and prolonging duration. Molecular docking revealed LQL's interaction with GABAA receptor (α1 and β2 subunits), supporting a GABAergic mechanism and highlighting its potential as a safe, natural sedative agent ...
Asifa Asrafi, Mohammad Aslam, Md. Sakib Al Hasan, Mohammed Burhan Uddin, Emon Mia, Mohammad Y. Alshahrani, Sumaya Akter Bithi, Mst. Sumaia Akter, Md. Arif Hossain, Md. Torequl Islam   +9 more
wiley   +1 more source

Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors

, 2015
Michael R. Post, Walrati Limapichat, Henry A. Lester, Dennis A. Dougherty   +3 more
openalex   +2 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia. [PDF]

Schizophr Res, 2018
Lewis AS, Olincy A, Buchanan RW, Kem WR, Picciotto MR, Freedman R.   +5 more
europepmc   +1 more source

Glucomannan from Dendrobium officinale Alleviates Colitis via Modulating Gut Microbiota and Upregulating Deoxycholic Acid Production

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary fiber is a bioactive substance that can modulate gut microbiota and exert a relieving effect on inflammatory bowel disease (IBD). Dendrobium officinale polysaccharide (DOP) is a type of bioactive dietary fiber that has been proven to have various biological activities on intestinal function.
Jie Xu, Shanshan Zhang, Qi Chen, Chenqing Xu, Siying Wu, Qiongni Lin, Zhipeng Li, Qixing Nie   +7 more
wiley   +1 more source