Results 131 to 140 of about 489,131 (311)

New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway

The Scientific World Journal, 2010
Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs ...
Xiao Hua Pan, Jianxin Zhang, Xiaowei Yu, Ling Qin, Ligeng Kang, Peng Zhang   +5 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Structural mechanism of muscle nicotinic receptor desensitization and block by curare

Nature Structural & Molecular Biology, 2022
Md Mahfuzur Rahman, T. Basta, J. Teng, Myeongseong Lee, Brady T. Worrell, M. H. Stowell, R. Hibbs   +6 more
semanticscholar   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

A tight coupling between β\u3csub\u3e2\u3c/sub\u3eY97 and β\u3csub\u3e2\u3c/sub\u3eF200 of the GABA\u3csub\u3eA\u3c/sub\u3e receptor mediates GABA binding [PDF]

, 2011
The GABAA receptor is an oligopentameric chloride channel that is activated via conformation changes induced upon the binding of the endogenous ligand, GABA, to the extracellular inter-subunit interfaces. Although dozens of amino acid residues at the α/β
Laha, Kurt T., Tran, Phu N., Wagner, David A.   +2 more
core   +1 more source

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Nematode parasites infect ∼2 billion people world-wide. Infections are treated and prevented by anthelmintic drugs, some of which act on nicotinic acetylcholine receptors (nAChRs).
Fudan Zheng, Xiangwei Du, Tsung-Han Chou, Alan P. Robertson, Edward W. Yu, Brett VanVeller, Richard J. Martin   +6 more
doaj   +1 more source

Slow synaptic transmission in frog sympathetic ganglia [PDF]

, 1986
Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R., Brown, D. A., Jones, S. W., Koch, Christof, Lancaster, B., Pennefeather, P.   +5 more
core   +2 more sources

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties [PDF]

, 2008
Karin Tietje, David J. Anderson, Robert S. Bitner, Eric A.G. Blomme, Paul J. Brackemeyer, Clark A. Briggs, Kaitlin E. Browman, Dagmar Bury, Peter Curzon, Karla Drescher, Jennifer M. Frost, Ryan M. Fryer, Gerard B. Fox, Jens Halvard Grønlien, Monika Håkerud, Earl J. Gubbins, Sabine Halm, Richard Harris, Rosalind Helfrich, Kathy L. Kohlhaas, Devalina Law, John Malysz, Kennan C. Marsh, Ruth L. Martin, Michael D. Meyer, Angela L. Molesky, Arthur L. Nikkel, Stephani Otte, Liping Pan, Pamela S. Puttfarcken, Richard J. Radek, Holly M. Robb, Eva Spies, Kirsten Thorin‐Hagene, Jeffrey F. Waring, Hilde Ween, Hongyu Xu, Murali Gopalakrishnan, William H. Bunnelle   +38 more
openalex   +1 more source

Activation of endplate nicotinic acetylcholine receptors by agonists [PDF]

Biochemical Pharmacology, 2015
The interaction of a small molecule made in one cell with a large receptor made in another is the signature event of cell signaling. Understanding the structure and energy changes associated with agonist activation is important for engineering drugs, receptors and synapses.
openaire   +2 more sources