Results 131 to 140 of about 33,509 (296)

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Nicotinic agonists antagonize quantal size increases and evoked release at frog neuromuscular junction. [PDF]

, 1993
W. Van der Kloot
openalex   +1 more source

Association between sodium‐glucose cotransporter 2 inhibitor use and clinical outcomes in patients with type 2 diabetes after urinary tract infection

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate whether initiating sodium‐glucose cotransporter 2 inhibitors (SGLT2i) within 3 months after a urinary tract infection (UTI) is associated with improved long‐term outcomes in patients with type 2 diabetes mellitus (T2DM), compared with dipeptidyl peptidase‐4 inhibitors (DPP‐4i).
Hsiao‐Wei Wang, Ming‐Hsien Tsai, Yu‐Wei Fang, Kuo‐Cheng Lu, Joshua Wang, Chien‐Lin Lu   +5 more
wiley   +1 more source

Dynaflow ™ 48, a microfluidic chip solution for increasing throughput and data quality in patch-clamp-based drug screening [PDF]

, 2006
Ion channels are transm embrane proteins, found in virtually all cell types throughout the human body. Ion channels underlie neural communication, memory, behavior, every movement and heartbeat, and are as such prone to cause disease if malfunctioning.
Granfeldt, Daniel, Johansson, Marie-Louise, Karlsson, Mattias, Pihl, Johan, Sinclair, Jon   +4 more
core  

In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains

, 2011
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core   +1 more source

Weight loss interventions and obesity‐associated cancers in people with type 2 diabetes and overweight/obesity: A real‐world observational study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate whether weight‐loss interventions are associated with obesity‐associated cancers (OAC) in individuals with overweight/obesity and type 2 diabetes (T2D). Materials and Methods This retrospective cohort study utilised the TriNetX federated research network.
Testimony Ipaye, Jonathan Goldney, Thomas J. Wilkinson, Francesco Zaccardi, Thomas Yates, Melanie J. Davies, Karen Brown, Dimitris Papamargaritis   +7 more
wiley   +1 more source

Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. [PDF]

J Clin Invest, 2020
Knowland D, Gu S, Eckert WA, Dawe GB, Matta JA, Limberis J, Wickenden AD, Bhattacharya A, Bredt DS.   +8 more
europepmc   +1 more source

Pharmacological Characterization of RJR‐2403: A Nicotinic Agonist with Potential Therapeutic Benefit in the Treatment of Alzheimer's Disease [PDF]

, 1997
Merouane Bencherif, Gary D. Byrd, William S. Caldwell, Jane Hayes, P M Lippiello   +4 more
openalex   +1 more source

Substance Use and Problem Gambling Interventions for People With Intellectual Disability: A Systematic Review

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Introduction People with intellectual disability (ID) face increased vulnerability to addictive behaviours, yet effective interventions are under‐researched. This study aimed to systematically review existing interventions for substance use and problem gambling in this population. Methods Following PRISMA guidelines, we searched Web of Science,
Amalia Udeanu, Gloria Garcia‐Fernandez, Andrea Krotter, Juan Antonio García‐Aller, Patricia Solis Garcia, Laura E. Gómez   +5 more
wiley   +1 more source

Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists. [PDF]

Med Hypotheses, 2020
Allahverdi Khani M, SalehiRad M, Darbeheshti S, Motaghinejad M.   +3 more
europepmc   +1 more source