Results 131 to 140 of about 32,658 (245)

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists. [PDF]

Med Hypotheses, 2020
Allahverdi Khani M, SalehiRad M, Darbeheshti S, Motaghinejad M.   +3 more
europepmc   +1 more source

Dynaflow ™ 48, a microfluidic chip solution for increasing throughput and data quality in patch-clamp-based drug screening [PDF]

, 2006
Ion channels are transm embrane proteins, found in virtually all cell types throughout the human body. Ion channels underlie neural communication, memory, behavior, every movement and heartbeat, and are as such prone to cause disease if malfunctioning.
Granfeldt, Daniel, Johansson, Marie-Louise, Karlsson, Mattias, Pihl, Johan, Sinclair, Jon   +4 more
core  

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.

PLoS ONE, 2013
Nicotinic acetylcholine receptors (nAChRs) are involved in seizure mechanisms. Hence, nocturnal frontal lobe epilepsy was the first idiopathic epilepsy linked with specific mutations in α4 or β2 nAChR subunit genes.
Monica Puligheddu, Giuliano Pillolla, Miriam Melis, Salvatore Lecca, Francesco Marrosu, Maria Graziella De Montis, Simona Scheggi, Gianfranca Carta, Elisabetta Murru, Sonia Aroni, Anna Lisa Muntoni, Marco Pistis   +11 more
doaj   +1 more source

Factors Associated With Cocaine Use Disorder: Results From the French Nationwide Repeated Cross‐Sectional OPPIDUM Study (2019–2023)

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Cocaine use has increased both globally and nationally. This trend is accompanied by a rise in clinical complications. The objective of our study was to identify factors observed to be associated with cocaine use disorder, using data from the OPPIDUM program, collecting information directly from patients with substance use disorders recruiting
Zenab Alhamidi, Clémence Lacroix, Elisabeth Jouve, Thomas Soeiro, Céline Eiden, Joëlle Micallef   +5 more
wiley   +1 more source

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Slow synaptic transmission in frog sympathetic ganglia [PDF]

, 1986
Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R., Brown, D. A., Jones, S. W., Koch, Christof, Lancaster, B., Pennefeather, P.   +5 more
core   +2 more sources

Contingency management interventions for substance use and addictive behaviours: Review of the United Kingdom evidence base

Addiction, Volume 121, Issue 4, Page 729-746, April 2026.
Abstract Background and aims Substance use and other addictive behaviours including gambling remain major public health concerns in the UK. Despite the effectiveness of substance use treatment approaches, treatment adherence and success rates remain low.
Carol‐Ann Getty, Tricia McQuarrie, Eileen Brobbin   +2 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source