Results 11 to 20 of about 489,131 (311)

Methamphetamine-like discriminative-stimulus effects of nicotinic agonists. [PDF]

J Pharmacol Exp Ther, 2014
Nicotine was recently shown to engender d-methamphetamine (MA)-like discriminative-stimulus effects in rats, which may be indicative of shared psychomotor stimulant properties. To further investigate such overlapping discriminative-stimulus effects, nicotinic agonists varying in efficacy and selectivity were studied in squirrel monkeys that ...
Desai RI, Bergman J.
europepmc   +5 more sources

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +2 more sources

Silent agonists for α7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states.
Roger L. Papke, Marta Quadri, Alican Gulsevin   +2 more
doaj   +3 more sources

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells [PDF]

Molecules, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Katrin Richter, Christian Koch, Alexander Perniss, Philipp M. Wolf, Elke K. H. Schweda, Sven Wichmann, Sigrid Wilker, Ilona Magel, Michael Sander, J. Michael McIntosh, Winfried Padberg, Veronika Grau   +11 more
doaj   +3 more sources

Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors. [PDF]

Nicotine Tob Res, 2014
Wageman CR, Marks MJ, Grady SR.
europepmc   +2 more sources

Cholinergic network modulation in disinhibited eating behavior [PDF]

Communications Biology
Cholinergic modulation of brain reward circuitry appears to play a crucial role in information processing about salience as a key biological mechanism in obesity. However, changes in acetylcholine transmission leading to abnormal eating behavior have not
Swen Hesse, Michael Rullmann, Tilman Günnewig, Eva Schweickert de Palma, Lara Burmeister, Max van Grinsven, Franziska Zientek, Julia Luthardt, Mohammed K. Hankir, Philipp M. Meyer, Georg-Alexander Becker, Marianne Patt, Peter Brust, Burkhard Pleger, Michael Stumvoll, Anja Hilbert, Matthias Blüher, Osama Sabri   +17 more
doaj   +2 more sources

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations [PDF]

EMBO Journal, 2005
Scott B. Hansen, Gerlind Sulzenbacher, Tom Huxford, P. Marchot, Palmer Taylor, Yves Bourne   +5 more
openalex   +2 more sources

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition [PDF]

Nature Communications
The α6β4 nicotinic acetylcholine receptor (nAChR) is found in the sensory neurons of dorsal root ganglia. It is a promising therapeutic target for pain.
Jiawei Su, Zhuoya Yu, Zhengji Yin, Zixuan Zhang, Jun Zhao, Yufei Meng, Renjie Li, Yiwei Gao, Hongwei Zhang, Rilei Yu, Yan Zhao   +10 more
doaj   +2 more sources

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

eLife, 2022
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cellular
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester   +18 more
doaj   +1 more source

Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity. [PDF]

PLoS ONE, 2012
Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop acute kidney injury (AKI) are at increased risk of death. To date there is no effective treatment for AKI or septic AKI.
Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz   +6 more
doaj   +1 more source