Results 11 to 20 of about 33,509 (296)

Nicotine receptor partial agonists for smoking cessation [PDF]

Sao Paulo Medical Journal, 2007
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). Varenicline was developed as a nicotine receptor partial agonist from cytisine, a drug widely used in central
Cahill, Kate, Stead, Lindsay F., Lancaster, Tim, Polonio, Igor Bastos   +3 more
openaire   +12 more sources

Nicotine receptor partial agonists for smoking cessation

Cochrane Database of Systematic Reviews, 2023
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). This is an update of a Cochrane Review first published in 2007.To assess the effectiveness of nicotine ...
Livingstone-Banks, J, Fanshawe, TR, Thomas, KH, Theodoulou, A, Hajizadeh, A, Hartman, L, Lindson, N   +6 more
openaire   +4 more sources

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

Molecules, 2023
Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at allosteric ...
Dina Manetti, Silvia Dei, Hugo R. Arias, Laura Braconi, Alessio Gabellini, Elisabetta Teodori, Maria Novella Romanelli   +6 more
doaj   +1 more source

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors [PDF]

Frontiers in Pharmacology, 2017
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I]-epibatidine binding, whole-cell patch-clamp recordings, synaptosomal 86Rb+ efflux, [3H]-dopamine release, and
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester   +12 more
openaire   +6 more sources

Cholinergic anti-inflammatory pathway and COVID-19 [PDF]

BioImpacts, 2022
The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
doaj   +1 more source

Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]

, 1994
Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core   +1 more source

Cognitive Enhancers in Schizophrenia: A Systematic Review and Meta-Analysis of Alpha-7 Nicotinic Acetylcholine Receptor Agonists for Cognitive Deficits and Negative Symptoms

Frontiers in Psychiatry, 2021
Background: Schizophrenia is a severe and enduring disease and is one of the leading causes of disability worldwide. Cognitive impairment is a core clinical symptom that plays a crucial role in functional outcomes and prognosis, thus making it a relevant
María Recio-Barbero, Rafael Segarra, Rafael Segarra, Rafael Segarra, Rafael Segarra, Arantzazu Zabala, Arantzazu Zabala, Arantzazu Zabala, Eduardo González-Fraile, Ana González-Pinto, Ana González-Pinto, Ana González-Pinto, Ana González-Pinto, Javier Ballesteros, Javier Ballesteros, Javier Ballesteros   +15 more
doaj   +1 more source

Nicotine receptor partial agonists for smoking cessation [PDF]

Cochrane Database of Systematic Reviews, 2016
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist).To review the efficacy of nicotine receptor partial agonists, including varenicline and cytisine, for smoking ...
Cahill, Kate, Lindson-Hawley, Nicola, Thomas, Kyla H, Fanshawe, Thomas R, Lancaster, Tim   +4 more
openaire   +5 more sources

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source