Results 21 to 30 of about 489,131 (311)

Acute activation, desensitization and smoldering activation of human acetylcholine receptors. [PDF]

PLoS ONE, 2013
The behavioral effects of nicotine and other nicotinic agonists are mediated by AChRs in the brain. The relative contribution of acute activation versus chronic desensitization of AChRs is unknown. Sustained "smoldering activation" occurs over a range of
Barbara G Campling, Alexander Kuryatov, Jon Lindstrom   +2 more
doaj   +1 more source

Suppression of methamphetamine-seeking behavior by nicotinic agonists. [PDF]

Proceedings of the National Academy of Sciences, 2006
To understand the mechanism of methamphetamine (MAP) craving from the viewpoint of nicotinic acetylcholinergic transmission, we examined the responsible site of the brain for anticraving effects produced by nicotinic agonists by using a MAP self-administration paradigm in rats.
T. Hiranita, Y. Nawata, K. Sakimura, K. Anggadiredja, Tsuneyuki Yamamoto   +4 more
semanticscholar   +3 more sources

Nicotine receptor partial agonists for smoking cessation [PDF]

Sao Paulo Medical Journal, 2007
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). Varenicline was developed as a nicotine receptor partial agonist from cytisine, a drug widely used in central
Cahill, Kate, Stead, Lindsay F., Lancaster, Tim, Polonio, Igor Bastos   +3 more
openaire   +17 more sources

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

Molecules, 2023
Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at allosteric ...
Dina Manetti, Silvia Dei, Hugo R. Arias, Laura Braconi, Alessio Gabellini, Elisabetta Teodori, Maria Novella Romanelli   +6 more
doaj   +1 more source

Nicotine receptor partial agonists for smoking cessation

Cochrane Database of Systematic Reviews, 2023
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). This is an update of a Cochrane Review first published in 2007.To assess the effectiveness of nicotine ...
Livingstone-Banks, J, Fanshawe, TR, Thomas, KH, Theodoulou, A, Hajizadeh, A, Hartman, L, Lindson, N   +6 more
openaire   +4 more sources

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

Cholinergic anti-inflammatory pathway and COVID-19 [PDF]

BioImpacts, 2022
The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
doaj   +1 more source

Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]

, 1994
Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core   +1 more source

Direct and GABA‐mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones

Journal of Physiology, 2012
Ruixi Luo, Megan J. Janssen, John G. Partridge, Stefano Vicini   +3 more
openalex   +3 more sources

Nicotinic Agonists, Antagonists, and Modulators From Natural Sources

Cellular and Molecular Neurobiology, 2005
1. Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. Several further nicotinic agonists have been discovered from natural sources, including cytisine, anatoxin, ferruginine, anabaseine, epibatidine, and epiquinamide.
J. Daly
semanticscholar   +3 more sources