Results 61 to 70 of about 1,050 (206)

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Unraveling the Complexity of Divalent Hydride Electrolytes in Solid‐State Batteries via a Data‐Driven Framework with Large Language Model

Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.
We present a data‐driven framework that combines experimental and computational information to accelerate the discovery of high‐performance divalent hydride solid‐state electrolytes, enabling precise predictions of activation energies and novel ionic migration mechanisms which are essential for next‐generation energy storage technology.
Qian Wang, Fangling Yang, Yuhang Wang, Di Zhang, Ryuhei Sato, Linda Zhang, Eric Jianfeng Cheng, Yigang Yan, Yungui Chen, Kazuaki Kisu, Shin‐ichi Orimo, Hao Li   +11 more
wiley   +2 more sources

Tethered N-Heterocyclic Carbene-Carboranes: Unique Ligands that Exhibit Unprecedented and Versatile Coordination Modes at Rhodium [PDF]

, 2016
Four brand new hybrid ligands combining an N-heterocyclic carbene tethered with two isomeric nido-dicarbaundecaborane dianions, a neutral closo-dicarbadodecaborane or a closo-dicarbadodecaborane anion are described.
Fox, MA, Holmes, J, Pask, CM, Willans, CE   +3 more
core   +3 more sources

Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy [PDF]

, 2014
The potential of boron-containing lipids with three different structures, which were intended for use in boron neutron capture therapy, was investigated. All three types of boron lipids contained the anionic dodecaborate cluster as the headgroup.
Detlef Gabel, Doaa Awad, Ekkehard Kuestermann, Franz M. Wagner, Markus Bergmann, Nan Jiang, Regine Suess, Rolf Schubert, Tanja Schaffran   +8 more
core   +2 more sources

Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells. [PDF]

, 2020
Owing to the involvement of cyclooxygenase-2 (COX-2) in carcinogenesis, COX-2-selective inhibitors are increasingly studied for their potential cytotoxic properties. Moreover, the incorporation of carboranes in structures of established anti-inflammatory
Buzharevski, Antonio, Hey-Hawkins, Evamarie, Laube, Markus, Lönnecke, Peter, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Murganić, Blagoje, Neumann, Wilma, Paskaš, Svetlana, Pietzsch, Jens, Sárosi, Menyhárt-Botond   +10 more
core   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue [PDF]

, 2023
All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyloid-β (
Basset, Gabriele, Draˇca, Dijana, Hey-Hawkins, Evamarie, Laube, Markus, Maksimovi´c-Ivani´c, Danijela, Pietzsch, Jens, Saretz, Stefan, Steiner, Harald, Trambauer, Johannes, Useini, Liridona   +9 more
core   +1 more source

Sviluppo e applicazioni della boron neutron capture therapy [PDF]

, 2017
La Boron Neutron Capture Therapy è una tecnica terapeutica altamente selettiva, utilizzata in oncologia, che si basa sulla reazione di cattura neutronica 10B(n,α)7Li .
Guidi, Claretta
core  

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Synthesis, Characterization and Evaluation of Central Nervous System Targeted Metallocarborane Complexes [PDF]

, 2011
A series of new methodologies to link a neurotransmitter receptor targeting vector (WAY) to carboranes and the preparation of the corresponding metallocarboranes (M = Re, 99mTc) as a new class of organometallic CNS imaging probes is described.
Louie, Anika S.
core