Two mRNA Transcripts for Inducible (type II) Nitric Oxide Synthase in Fetal, Newborn, and Adult Ovine Lung. • 1960 [PDF]
Pediatric Research, 1998 Although the inducible (type II) Nitric Oxide synthase isoform (iNOS) has been identified in the normal fetal lung, little is known about changes in iNOS expression in the lung during fetal and postnatal development. We studied qualitative and quantitative changes in iNOS mRNA expression in the lungs of fetal, newborn and adult sheep.
Timothy D. Le Cras +2 more
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A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes [PDF]
Osteoarthritis and Cartilage, 2008 Recent studies revealed a close connection between adipose tissue, adipokines and articular degenerative inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). The goal of this work was to investigate the activity of adiponectin in human and murine chondrocytes and to study its functional role in the modulation of nitric oxide
R. Lago +7 more
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Effects of cardiovascular angiotensin II type 1 receptor blockade on nitric oxide synthase inhibition in patients with insulin resistance syndrome [PDF]
Blood Pressure, 2009 There is evidence that in the early stages of type II diabetes, the cardiovascular system compensates by increasing endothelial nitric oxide synthase (e-NOS) expression. In the advanced stages of disease, e-NOS is diminished, and is associated with endothelial dysfunction.
Divina Gracilla Brillante +3 more
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Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes [PDF]
Journal of Biological Chemistry, 1996 Incubation of primary cultures of rat hepatocytes with lipopolysaccharide (LPS), S-[2,3-bis(palmitoyloxy)-(2-R,S)-propyl]-N-palmitoyl-(R)-Cys-Ser-Lys4 (TPP), a synthetic lipopeptide present in bacterial cell wall lipoproteins, or with phorbol 12,13-dibutyrate (PDBu) induced an increase in nitric oxide synthesis through the expression of type II nitric ...
María José Guerra Palmero +3 more
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Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection [PDF]
Journal of Neuroimmunology, 1997 Intranasal inoculation with mouse hepatitis virus strain JHM (MHV-JHM) results in acute meningoencephalitis. We found NOS II mRNA expression in brains of acutely infected animals on days 5 through 7 after infection. In situ hybridization and immunohistochemistry demonstrated NOS II message and protein in infiltrating macrophages.
Dana M. Grzybicki +3 more
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Nitric Oxide Differentially Regulates Induction of Type II Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells Versus Macrophages [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Abstract —We studied effects of nitric oxide (NO) released by different NO donors on induction of inducible NO synthase (iNOS) in rat aortic smooth muscle cells (RASMC) and rat macrophage cell line NR8383. iNOS protein expression induced by a CM (interleukin-1β 250 U/mL, interferon-γ 150 U/mL, and tumor necrosis factor-α 150 U ...
Hanfang Zhang +2 more
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Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy [PDF]
Nephrology Dialysis Transplantation, 2008 Recent studies showed that angiotensin II type 1 receptor blocker (ARB) slows progression of chronic renal disease in patients with type 2 diabetes, regardless of changes in blood pressure. We showed that the imbalance of nitric oxide (NO) and reactive oxygen species (ROS) due to endothelial NO synthase (eNOS) uncoupling contributed to renal ...
Masataka Satoh +8 more
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Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression. [PDF]
The Journal of Immunology, 1997 Abstract Triggering of RAW 264.7 cells with a cecropin A-melittin hybrid peptide (CA(1-8)M(1-18)) promoted a rapid rise in the intracellular calcium concentration that was followed, after a lag period of 6 h, by nitric oxide synthesis through the expression of the cytokine-inducible form of nitric oxide synthase (type II NOS or iNOS ...
Marta Velasco Santiago +5 more
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Journal of Cardiovascular Pharmacology, 2000 We evaluated the effects of long-term treatment with TCV-116, an angiotensin II type 1 receptor antagonist, on endothelial-cell nitric oxide synthase (eNOS) messenger RNA (mRNA) and protein expression in the left ventricle and its relation to myocardial remodeling in Goldblatt hypertensive rats.
Teruo Higashi +4 more
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Brazilian Journal of Otorhinolaryngology, 2006 In experimental endolymphatic hydrops distortion-products otoacoustic emission (dpoae) amplitudes decrease and there is elevation on electrocochleographic thresholds. Some authors found type ii nitric oxide synthase (nos ii) expression in hydropic cochleas and they suggest nitric oxide (no) may be involved in endolymphatic hydrops pathogenesis. The aim
Cláudio Márcio Yudi Ikino +3 more
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