A high-throughput screening method for determining the substrate scope of nitrilases [PDF]
Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and
Black, Gary+5 more
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ON THE PREPARATION OF FUMARIC NITRILE. THE ACTION OF HYDROXYLAMINE ON FUMARIC NITRILE. [PDF]
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McMaster, L., Langreck, F. B.
openaire +2 more sources
Comparison of C═C bond hydrogenation in C-4 unsaturated nitriles over Pt/alumina [PDF]
The hydrogenation of allyl cyanide (but-1-ene-4-nitrile, AC), trans- and cis-crotononitrile (E- and Z-but-2-ene nitrile, TCN and CCN), and methacrylonitrile (2-cyano-1-propene, MCN) were studied, both singly and competitively, over a Pt/alumina catalyst ...
Andrew Monaghan+3 more
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Exposure to ultraviolet B (UVB) irradiation of the skin leads to numerous dermatological concerns including skin cancer and accelerated aging. Natural product glucosinolate derivatives, like sulforaphane, have been shown to exhibit chemopreventive and ...
Evan L. Carpenter+14 more
doaj +1 more source
Identification of an Active Site-bound Nitrile Hydratase Intermediate through Single Turnover Stopped-flow Spectroscopy [PDF]
Stopped-flow kinetic data were obtained for the iron-type nitrile hydratase from Rhodococcus equi TG328-2 (ReNHase) using methacrylonitrile as the substrate.
Gumataotao, Natalie+3 more
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Crystal structures of methyl 3,5-dibromo-4-cyanobenzoate and methyl 3,5-dibromo-4-isocyanobenzoate
The title crystals, C9H5Br2NO2, are the first reported 2,6-dihalophenyl cyanide–isocyanide pair that have neither three- nor two-dimensional isomorphism. Both crystals contain contacts between the carbonyl O atom and a Br atom.
Wayland E. Noland+4 more
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Nitrile hydratase genes are present in multiple eukaryotic supergroups. [PDF]
Nitrile hydratases are enzymes involved in the conversion of nitrile-containing compounds into ammonia and organic acids. Although they are widespread in prokaryotes, nitrile hydratases have only been reported in two eukaryotes: the choanoflagellate ...
Alan O Marron+2 more
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Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F+6 more
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7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile
The title compound was prepared by electrophilic aromatic substitution of 7-bromo-1-methyl-2-phenyl-1H-indole with NCTS (N-cyano-N-phenyl-p-toluenesulfonamide).
Rosanna Meine+3 more
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2,6-Dibromo-4-nitrobenzonitrile
Molecules of the title compound, C7H2Br2N2O2, have C2v symmetry and each lie on a twofold axis that bisects the benzene ring and its nitro and cyano substituents.
Wayland E. Noland, Kenneth J. Tritch
doaj +1 more source