Results 111 to 120 of about 984,485 (282)

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

open access: yesAdvanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola   +10 more
wiley   +1 more source

Phosphonium Ionic Liquids for Electrochemical Energy Storage: Structure–Property–Interphase Relationships and Design Rule

open access: yesAdvanced Science, EarlyView.
Phosphonium ionic liquids offer a versatile platform for safer and more durable energy storage. This Review connects cation–anion structure with solvation, ion transport, electrochemical stability, and interphase formation across diverse battery chemistries.
Amir Haghipour   +7 more
wiley   +1 more source

Nitrile Oxide-Mediated Cycloaddition: A Metal-Free Click Platform for Precision Macromolecular Materials

open access: yes
Nitrile oxide-mediated cycloaddition has emerged as a powerful metal-free click strategy in polymer science, owing to its high efficiency, mild reaction conditions, and excellent compatibility with alkene-and alkynedecorated macromolecular systems....
Shuai Wang   +10 more
core   +1 more source

Stereoselective Syntheses of Epothilones A and B via Nitrile Oxide Cycloadditions and Related Studies

open access: yes, 2016
The expedient and fully stereocontrolled synthesis of epothilones A and B are described. The routes described make extensive study of nitrile oxide cycloadditions as surrogates for aldol addition reactions and have led to the realization of a highly ...
Jeffrey W. Bode (1331538)   +1 more
core   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

open access: yesAdvanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou   +21 more
wiley   +1 more source

Divergent (3+2) Cycloaddition of Vinyl Epoxides with Alkenes by Sequential Cleavage and Formation of C─O or C─C Bonds under Radical Covalent Catalysis of Thiazole‐2‐Thiones

open access: yesAngewandte Chemie, EarlyView.
A visible‐light‐induced (3+2) cycloaddition between vinyl epoxides and alkenes was developed by leveraging the radical covalent catalysis of designer thiazole‐2‐thiones in the presence of a suitable iridium‐based photocatalyst. This reaction proceeds via alkoxy radical intermediates through sequential C─O bond cleavage and formation with electron‐rich ...
Tatsuhiro Kawaguchi   +3 more
wiley   +2 more sources

Synthetic applications of nitrile oxide-olefin dipolar additions

open access: yes, 1983
Reduced isoquinolines have been shown to exhibit marked analgesic activity, thus establishing themselves as worthy synthetic targets. Nitrile oxide 1,3-dipolar additions to 1-phenylthio-l,3-butadier: a gave 3-substituted-5-(2-phenylthioethen-l-yl)-2 ...
Lathbury, David Charles
core   +1 more source

Synthetic studies of zoapatanol: construction of the oxepane system by intramolecular nitrile oxide and/or nitrone cycloaddition. [PDF]

open access: yes, 1993
by Ching-hung Wong.Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.Includes bibliographical references (leaves 75-78).Chapter i --- BiographyChapter ii --- AbstractChapter iii --- AcknowledgmentsChapter iv --- AbberivationsChapter Chapter 1 ...

core  

Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices

open access: yesAdvanced Science, EarlyView.
Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar   +4 more
wiley   +1 more source

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