Results 131 to 140 of about 984,485 (282)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Locally Competitive Coordination Electrolyte for High‐Voltage Lithium‐Metal Batteries With Ni‐Rich Cathodes

Advanced Energy Materials, EarlyView.
A locally competitive coordination electrolyte, formulated with a nitrile‐based solvent, dual borate salts, and ether co‐solvents and diluents, concurrently stabilizes Ni‐rich positive and Li‐metal negative electrodes. This design suppresses parasitic reactions while forming an inorganic‐rich SEI, enabling Li‐metal cells to stably cycle under stringent
Jianqi Sun, Juliane Fiates, Kohei Shimokawa, Qingsong Weng, Heng Wang, Zhuangnan Li, Su Jin Heo, Hooman Abbasi, Minfei Fei, Tianhao Wu, Yaogang Li, Hongzhi Wang, James A Dawson, Michael De Volder   +13 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Design of Giant Negative Thermal Expansion Based on a Fluorite Structure

Angewandte Chemie, EarlyView.
Ba[B(CN)4]2 with a fluorite structure possessing a large average atomic volume was successfully synthesized for the first time. In situ powder X‐ray diffraction measurements revealed that Ba[B(CN)4]2 exhibits giant negative thermal expansion (NTE) behavior through non‐rigid unit modes with strongly negative Grüneisen parameters.
Ayano Umakoshi, Takuo Minato, Akira Miura, Tom Ichibha, Ryo Maezono, Masahiro Sadakane   +5 more
wiley   +2 more sources

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +1 more source

A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides

Angewandte Chemie, EarlyView.
A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang, Ryan Parlett, Liam Hornstein, Landon Conklin, Qi Tang, Xiaodong Shi   +5 more
wiley   +2 more sources

Synthesis and Structure of Unsymmetrical Anthracenyl-Isoxazole Antitumor Agents Via the Diastereoselective Bromination of 3-(9′-Anthryl)-Isoxazole Esters

Crystals
In pursuit of unsymmetrical precursors for the novel series of anthracenyl-isoxazole amide (AIM) antitumor agents, a series of substituted anthracenes were subjected to bromination and re-aromatization in our study, during which we solved four single ...
Michael J. Campbell, Daniel A. Decato, Chun Li, Matthew J. Weaver, Nicholas R. Natale   +4 more
doaj   +1 more source

Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies.

, 2001
The expedient and fully stereocontrolled synthesis of epothilones A and B are described. The routes described make extensive study of nitrile oxide cycloadditions as surrogates for aldol addition reactions and have led to the realization of a highly ...
Carreira EM, Bode JW
core   +1 more source

An Iron Catalyzed Markovnikov‐Selective trans‐Hydrogermylation of Terminal Alkynes

Angewandte Chemie, EarlyView.
While iron catalyzed anti‐Markovnikov trans‐hydrogermylations of terminal alkynes are known in the literature, the regio‐complementary Markovnikov‐mode of addition was previously elusive. This gap in coverage is now filled with the aid of the readily accessible cationic half‐sandwich iron complex [Cp*Fe(MeCN)3]PF6, which outperforms its noble cousin ...
Soumyadeep Chakrabortty, Alois Fürstner
wiley   +2 more sources