Results 91 to 100 of about 252,458 (275)

Asymmetric one-pot synthesis of cyclopropanes

Macedonian Journal of Chemistry and Chemical Engineering, 2016
Cycloaddition of the diazoalkanes to electron-deficient olefins (in situ) affords polysubstituted cyclopropanes in high yields (up to 85%). Deprotection of the ketal protecting group provided water-soluble cyclopropane-bearing carbohydrate in good yields.
Naoufel Ben Hamadi, Ahlem Guesmi, Wided Nouira   +2 more
doaj   +1 more source

Intermolecular 1,3-dipolar cycloaddition of nitrile oxides with vinyl acetate and acrylonitrile [PDF]

, 1997
Reaction of several nitrile oxides 2, isolated from the oxidative dehydrogenation of aldoximes by chloramine-T, with vinyl acetate and acrylonitrile proceeds in better yield than if the nitrile oxides are generated in situ.
Rai, K. M. Lokanatha, Rai, K M Lokanatha, Hassner, Alfred, Hassner, A.   +3 more
core  

Fluorine-Activated and -Directed Allene Cycloadditions with Nitrile Oxides and Imine Oxides: Synthesis of Ring-Fluorinated Isoxazole Derivatives

, 2023
In this study, 1,1-difluoroallenes underwent a regioselective [2+3] cycloaddition with nitrile oxides and imine oxides in the presence of a AuCl catalyst.
Sho Nakazono, Junji Ichikawa (1433815), Kohei Fuchibe, Kyosuke Suto, Kohei Fuchibe (1470610), Kazuki Sakon (17048549), Reo Eto, Reo Eto (17048555), Sho Nakazono (17048558), Junji Ichikawa, Kazuki Sakon, Kyosuke Suto (17048552)   +11 more
core   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene)penicillanate: batch, microwave-induced and continuous flow methodologies. [PDF]

RSC Adv, 2022
Alves AJS, Silvestre JAD, Pinho E Melo TMVD.   +2 more
europepmc   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Does electrophilic activation of nitroalkanes in polyphosphoric acid involve formation of nitrile oxides? [PDF]

RSC Adv, 2021
Aksenov AV, Aksenov NA, Kirilov NK, Skomorokhov AA, Aksenov DA, Kurenkov IA, Sorokina EA, Nobi MA, Rubin M.   +8 more
europepmc   +1 more source

Synthesis of Highly Reactive Polymer Nitrile N‑Oxides for Effective Solvent-Free Grafting

, 2016
A one-pot synthesis of polymer nitrile N-oxides was achieved via the Michael addition of living polymer anions derived from vinyl monomers to commercially available trans-β-nitrostyrene and subsequent dehydration with concd H2SO4.
Satoshi Uchida (281774), Toshikazu Takata (1442374), Chen-Gang Wang (1832977), Yasuhito Koyama (1442377)   +3 more
core   +1 more source

Protonation Modification of Commercial OPBI as Binders Toward High‐Performance High‐Temperature PEM Fuel Cells

Advanced Science, EarlyView.
Commercial OPBI binders is regulated via a facile formic‐acid protonation strategy without disrupting the polymer backbone. Protonation introduces positively charged benzimidazole sites, inducing interchain electrostatic repulsion that loosens chain packing, enlarges intermolecular spacing, and promotes uniform binder dispersion over catalyst surfaces.
Jinzhen Huang, Minhui Liang, Jingjing Lin, Zhihuan Pan, Jinwu Peng, Lei Wang   +5 more
wiley   +1 more source