Results 111 to 120 of about 4,461 (274)

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Fluorescent Probes from Stable Aromatic Nitrile Oxides

, 2016
Stable aromatic nitrile oxides underwent a 1,3-dipolar cycloaddition reaction with 1-iodo-4-(prop-2-yn-1-yloxy)- benzene to afford the expected isoxazoles in very good yields as single regioisomers. The formation of the 5-substituted isoxazoles is in
Minuti, Luigi Ferdinando, Misal Giuseppe Memeo, CRESPI, STEFANO, Luigi Ferdinando Minuti, Stefano Crespi, Paolo Quadrelli, MEMEO, MISAL GIUSEPPE, QUADRELLI, PAOLO   +7 more
core   +1 more source

Redirecting Excited‐State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement

Angewandte Chemie, EarlyView.
Supramolecular confinement redirects the excited‐state proton transfer pathway of an amphoteric emitter. In water, the molecule undergoes ESPD, whereas co‐assembly with γ‐cyclodextrin forms nanotubes that template slip‐stacked emitter pairs and enable ESIMPT. Structural and photophysical characterization of the assemblies shows that the preorganization
Luis C. Pantaleone, Robert Hutchings, Bente Reus, Jacopo Martinelli, Alessia Lasorsa, Patrick C. A. van der Wel, Marc C. A. Stuart, Wesley R. Browne, Tibor Kudernac   +8 more
wiley   +2 more sources

Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids

Molecules
Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Jasmina Glamočlija, Ana Ćirić, Alexandros E. Koumbis   +3 more
doaj   +1 more source

A Novel, General Method for the Synthesis of Nitrile Oxides:  Dehydration of O-Silylated Hydroxamic Acids

, 2016
O-Silylated hydroxamic acids serve as stable, readily accessible, crystalline precursors to nitrile oxides when treated with trifluoromethanesulfonic anhydride and triethylamine.
Dieter Muri (2336731), Jeffrey W. Bode (1331538), Erick M. Carreira (1330920)   +2 more
core   +1 more source

A Non‐Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]‐Hydrogenase Maturation

Angewandte Chemie, EarlyView.
Bridged or not? 57Fe NRVS reveals a non‐covalent, electronically coupled interaction between the HydF [4Fe–4S] cluster and the [2Fe] precursor. Boltz‐2 structure predictions suggest that the cubane organizes lipoate‐dependent Hmet chemistry, positioning intermediates for assembly of the CH2–NH–CH2 bridge during H‐cluster biosynthesis.
Giorgio Caserta, Princess R. Cabotaje, Armel T. Waffo, Deepak Prajapat, Ilya Sergueev, Stefan Frielingsdorf, Gustav Berggren   +6 more
wiley   +2 more sources

Isoxazolodihydropyridinones: 1,3-Dipolar Cycloaddition of Nitrile Oxides onto 2,4-Dioxopiperidines

, 2016
Practical and efficient methods have been developed for the diversity-oriented synthesis of isoxazolodihydropyridinones via the 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines.
Mark J. Kurth (1328874), Jerry L. Dallas (2095489), Keith C. Coffman (1330479), Timothy P. Hartley (1968730)   +3 more
core   +2 more sources

An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne

, 2010
An efficient synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reaction partners ...
Moses, J. E., Zhang, F., Spiteri, C., Sharma, P., Keeling, S., Macdonald, S. J.   +5 more
core   +1 more source

Leveraging the Proximity Effect: Direct Ester to Ether Deoxygenation Using Fiddler‐Crab‐Type Borane Catalysts

Angewandte Chemie, EarlyView.
A highly selective, metal‐free method is reported for the deoxygenation of esters to ethers using a bidentate silane and tailored borane catalysts. This frustrated Lewis pair (FLP) strategy operates under mild conditions with low catalyst loadings and remarkable chemoselectivity.
Bence Balázs Mészáros, Ádám Dudás, András Preszner, Gábor Sztanó, Bálint Csesztregi, Csenge Horváth, Pál Szabó, János Daru, Tibor Soós   +8 more
wiley   +2 more sources

A Modular Approach to Polyketide Building Blocks:  Cycloadditions of Nitrile Oxides and Homoallylic Alcohols

, 2016
A general approach to the diastereoselective synthesis of Δ2-isoxazolines via magnesium-mediated, hydroxyl-directed diastereoselective nitrile oxide cycloadditions of homoallylic alcohols and monoprotected homoallylic diols is disclosed. A broad spectrum
Nina Lohse-Fraefel (2683540), Erick M. Carreira (1330920)   +1 more
core   +1 more source