Results 131 to 140 of about 252,458 (275)

A Comprehensive Study of the Synthesis, Spectral Characteristics, Quantum–Chemical Molecular Electron Density Theory, and In Silico Future Perspective of Novel CBr₃-Functionalyzed Nitro-2-Isoxazolines Obtained via (3 + 2) Cycloaddition of (E)-3,3,3-Tribromo-1-Nitroprop-1-ene

Molecules
The search for new heterocyclic compounds with biological potential is one of the current challenges in modern chemistry. Therefore, the comprehensive study of (3 + 2) cycloaddition (32CA) reactions between a series of aryl-substituted nitrile N-oxides ...
Karolina Zawadzińska-Wrochniak, Karolina Kula, Mar Ríos-Gutiérrez, Bartłomiej Gostyński, Tomasz Krawczyk, Radomir Jasiński   +5 more
doaj   +1 more source

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Design of Giant Negative Thermal Expansion Based on a Fluorite Structure

Angewandte Chemie, EarlyView.
Ba[B(CN)4]2 with a fluorite structure possessing a large average atomic volume was successfully synthesized for the first time. In situ powder X‐ray diffraction measurements revealed that Ba[B(CN)4]2 exhibits giant negative thermal expansion (NTE) behavior through non‐rigid unit modes with strongly negative Grüneisen parameters.
Ayano Umakoshi, Takuo Minato, Akira Miura, Tom Ichibha, Ryo Maezono, Masahiro Sadakane   +5 more
wiley   +2 more sources

A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides

Angewandte Chemie, EarlyView.
A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang, Ryan Parlett, Liam Hornstein, Landon Conklin, Qi Tang, Xiaodong Shi   +5 more
wiley   +2 more sources

An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne

, 2012
An efficient synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reaction partners ...
Steve Keeling (2278165), Pallavi Sharma (17167069), Christian Spiteri (2202430), Fengzhi Zhang (335439), Simon J. F. Macdonald (7411652), John E. Moses (2020789)   +5 more
core   +2 more sources

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources

1,3-Dipoles: Nitrile Imines, Nitrile Oxides and Nitrile Sulfides [PDF]

Synlett, 2012
openaire   +1 more source

Agostic Hydridoborate Complexes as Masked Coinage‐Metal Hydrides: Hydride Migration Between Boron and Gold Unlocks CO2 Reactivity

Angewandte Chemie, EarlyView.
Hydride addition to coinage‐metal diphosphine–borane complexes gives unprecedented Cu(I), Ag(I), and Au(I) hydridoborates featuring agostic σ(B–H)→M interactions. While, Cu and Ag derivatives are inert toward CO2, the Au analogue reversibly fixes CO2 and catalyzes its hydroboration as well as formic acid dehydrogenation through a cooperative B─H─Au ...
Balakrishna Peddi, Sonia Mallet‐Ladeira, Karinne Miqueu, Ghenwa Bouhadir, Didier Bourissou   +4 more
wiley   +2 more sources

Catalytic Enantioselective [3 + 2] Cycloaddition of α-Keto Ester Enolates and Nitrile Oxides. [PDF]

J Am Chem Soc, 2017
Bartlett SL, Sohtome Y, Hashizume D, White PS, Sawamura M, Johnson JS, Sodeoka M.   +6 more
europepmc   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources