Results 121 to 130 of about 252,458 (275)

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope
An efficient and common strategy for the generation of pharmaceutically relevant functionalized molecules based on the diversity‐ and lead‐oriented synthesis (DOS/LOS)‐like concepts is presented. The approach is implemented for the case of functionalized
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
doaj   +1 more source

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

A modular approach to polyketide building blocks: cycloadditions of nitrile oxides and homoallylic alcohols.

, 2005
A general approach to the diastereoselective synthesis of Delta(2)-isoxazolines via magnesium-mediated, hydroxyl-directed diastereoselective nitrile oxide cycloadditions of homoallylic alcohols and monoprotected homoallylic diols is disclosed.
Carreira EM, Lohse-Fraefel N
core   +1 more source

A Closed‐Loop Direct Recycling Process for Prussian White From Scrap and End‐of‐Life Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
A closed‐loop direct recycling route for Prussian White sodium‐ion battery cathodes is demonstrated. Ice‐stripped scrap and end‐of‐life electrodes are regenerated via low‐temperature aqueous resodiation (80°C), restoring sodium content, Fe2+ redox chemistry, and structural integrity.
Subha Samanta, Bowen Liu, Dongrui Xie, Joel Cornelio, Wilgner Lima da Silva, Manoj Mayaji Ovhal, Anton Zorin, Peter R. Slater, Emma Kendrick   +8 more
wiley   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

1,3-Dipolar cycloadditions of acridine with nitrile oxides

ARKIVOC, 2002
Antonino Corsaro, Venerando Pistarà, Antonio Rescifina, Giovanni Romeo, Roberto Romeo, Ugo Chiacchio   +5 more
doaj   +1 more source

Facile synthesis of isoxazoline-bispirooxindoles via the 1,3-dipolar cycloaddition of nitrile oxides with isoindigos

An efficient 1,3-dipolar cycloaddition of nitrile oxides and isoindigos has been disclosed, enabling straightforward access to diverse isoxazoline-bispirooxindoles with vicinal quaternary spirocenters in moderate to excellent yields with high ...
Chengjian Cao, Lifu Duan, Song Hu, Yu-Long Li, Jian Wang, Yao Wan, Chenyi Li, Heng Yin, Shuangle Li   +8 more
core   +1 more source

Locally Competitive Coordination Electrolyte for High‐Voltage Lithium‐Metal Batteries With Ni‐Rich Cathodes

Advanced Energy Materials, EarlyView.
A locally competitive coordination electrolyte, formulated with a nitrile‐based solvent, dual borate salts, and ether co‐solvents and diluents, concurrently stabilizes Ni‐rich positive and Li‐metal negative electrodes. This design suppresses parasitic reactions while forming an inorganic‐rich SEI, enabling Li‐metal cells to stably cycle under stringent
Jianqi Sun, Juliane Fiates, Kohei Shimokawa, Qingsong Weng, Heng Wang, Zhuangnan Li, Su Jin Heo, Hooman Abbasi, Minfei Fei, Tianhao Wu, Yaogang Li, Hongzhi Wang, James A Dawson, Michael De Volder   +13 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources