Results 91 to 100 of about 19,627 (213)

Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode [PDF]

, 1997
The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed
Brett, Ana Maria Oliveira, Gutz, Ivano G. R., La-Scalea, Mauro A., Serrano, Sílvia H. P.   +3 more
core   +1 more source

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma [PDF]

, 2017
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors.
Alama, Alexiou, Amarante-Mendes, Ashkenazi, Ashkenazi, Ashkenazi, Borad, Botter, Campanacci, Chan, Chawla, Chirgwin, Dine, Duan, Ferrari, Goltzman, Goltzman, Goltzman, Gralow, He, Herbst, Holland, Holland, Kindler, Labrinidis, Liapis, Liapis, Link, Lustberg, Miharada, Mundy, Pringle, Robak, Saeter, Soria, Takeda, Tang, Taube, Wilson, Wojtkowiak, Yang, Younes, Zinonos   +42 more
core   +1 more source

2-Chloro-N-[(4-chlorophenyl)(phenyl)methyl]-N-[2-(4-nitro-1H-imidazol-1-yl)ethyl]ethanamine

Acta Crystallographica Section E, 2011
In the title compound, C20H20Cl2N4O2, the nitroimidazole ring makes dihedral angles of 17.00 (1) and 60.45 (11)° with the phenyl and chlorophenyl rings, respectively. The three-coordinate N atom connected to two methylene and
Wen-Tai Zhang, Cheng-He Zhou, Qing-Gang Ji   +2 more
doaj   +1 more source

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in helicobacter pylori infection [PDF]

, 2017
In this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in Helicobacter pylori (Hp) eradication, as well as the updated treatment strategies for this infection.
De Angelis, Massimiliano, Mascellino, Maria Teresa, Oliva, Alessandra, Porowska, Barbara   +3 more
core   +1 more source

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

Frontiers in Chemical Biology
In the last 60 years, the broad spectrum of activity of nitroimidazole derivatives against anaerobic bacteria, parasites, and protozoa has permitted their use as the first choice of treatment for many infectious diseases.
Walter Fugarolas, Lorena Reyes-Carmona, Bruno Landeros-Rivera, Argelia Almaguer-Flores, Norah Barba-Behrens   +4 more
doaj   +1 more source

Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

Future Pharmacology
Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez, Edgar López-López, Catalina Soriano-Correa, Carolina Barrientos-Salcedo   +3 more
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Structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles

Heterocyclic Communications
As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted.
Paoli-Lombardo Romain, Primas Nicolas, Hutter Sébastien, Castera-Ducros Caroline, Jacquet Inès, Verhaeghe Pierre, Azas Nadine, Rathelot Pascal, Vanelle Patrice   +8 more
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NanoPET imaging of [18F]fluoromisonidazole uptake in experimental mouse tumours [PDF]

, 2018
Purpose: The purpose of this study was to assess the potential and utility of ultra-high-resolution hypoxia imaging in various murine tumour models using the established hypoxia PET tracer [18F]fluoromisonidazole ([18F]FMISO).
Ametamey, Simon, Honer, Michael, Schubiger, Pius, Wyss, Matthias   +3 more
core  

CRISPR Screening and Comparative LC‐MS Analysis Identify Genes Mediating Efficacy of Delamanid and Pretomanid against Mycobacterium tuberculosis

Advanced Science
Tuberculosis (TB), the leading cause of death from bacterial infections worldwide, results from infection with Mycobacterium tuberculosis (Mtb). The antitubercular agents delamanid (DLM) and pretomanid (PMD) are nitroimidazole prodrugs that require ...
Mei‐Yi Yan, Haifeng Li, Yun‐Mo Qu, Si‐Shang Li, Dandan Zheng, Xiao‐Peng Guo, Zhaojun Wu, Jie Lu, Yu Pang, Weimin Li, Jian Yang, Lingjun Zhan, Yi‐Cheng Sun   +12 more
doaj   +1 more source

NITROIMIDAZOLES VII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACT I V I T I E S OF 4 - S U B S T I T U T E D - 2 - TWIAZOLYLHYDRAZONES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3).
doaj