Results 81 to 90 of about 15,048 (225)

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, Volume 2, Issue 2, June 2026.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Divergent Resilience of Bacterial and Fungal Gut Microbiota After Colorectal Surgery: Insights From a Prospective Longitudinal Cohort Study

MedComm, Volume 7, Issue 6, June 2026.
Patients undergoing colorectal surgery (n = 59) were sampled before and after surgery to investigate perioperative microbiome dynamics. Using 16S rRNA and ITS2 genes amplicon sequencing, bacterial diversity significantly decreased postoperatively, while fungal communities remained resilient.
Simon Wetzel, Eva Kohnert, Roman Huber, Alexander Müller, Agnes Knott, Lampros Kousoulas, Clemens Kreutz, Mohamed Tarek Badr, Ann‐Kathrin Lederer   +8 more
wiley   +1 more source

Synthesis, Crystal Structure, Hirshfeld Surface, RDG, ELF, LOL, DFT, and Molecular Docking Studies of a Binuclear Copper(II) Carboxylate Complex

ChemistryOpen, Volume 15, Issue 6, June 2026.
A binuclear copper(II) phenylacetate–metronidazole complex was successfully synthesized and structurally characterized. Hirshfeld surface analysis confirmed dominant H···H interactions governing crystal packing stability. DFT calculations demonstrated strong agreement with experimental geometry.
Abiodun Atoyebi Ajibola, Mehran Feizi‐Dehnayebi, Senem Akkoc, Lesław Sieroń, Waldemar Maniukiewicz   +4 more
wiley   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides

, 2020
Purpose. The use of fractionated radiotherapy has underpinned cancer therapy for the last 50 years and currently more than 50% of all cancer patients receive radiotherapy as part of their treatment. A new innovation in radiotherapy delivery, stereotactic
Jamieson, S, Hicks, KO, Hay, MP, Liew, L, Wong, W, Anderson, RF   +5 more
core  

Catalytic ozonation of nitroimidazole antibiotics using nano-magnesium hydroxide as heavy-metals free catalyst

, 2019
In this study, nano-magnesium hydroxide (nano-Mg(OH)(2)) was prepared and first applied for the catalytic ozonation of the widely used nitroimidazole antibiotics. Most of nitroimidazole antibiotics were rapidly removed within 10 min.
Sun, Q, Zhang, ZH, Wu, J, Zhu, GC, Lu, J
core   +1 more source

Core Shell Investigation of 2-nitroimidazole [PDF]

, 2019
Tunability and selectivity of synchrotron radiation have been used to study the excitation and ionization of 2-nitroimidazole at the C, N, and O K-edges.
Castrovilli, M., Sementa, L., Marinkovic, Bratislav P., Barcaro, G., Vincenzo Carravetta, Jacopo Chiarinelli, Chiarinelli, J., Bolognesi, Paola, Barcaro, Giovanni, Giovanni Barcaro, Bolognesi, P., Monti, Susanna, Mattea C. Castrovilli, Carravetta, V., Preeti Manjari Mishra, Lorenzo Avaldi, Manjari Mishra, Preeti, Luca Sementa, Sementa, Luca, Chiarinelli, Jacopo, Mishra, P., Antonella Cartoni, Sanja Tosic, Castrovilli, Mattea C., Monti, S., Robert Richter, Carravetta, Vincenzo, Richter, Robert, Marinkovic, B., Avaldi, Lorenzo, Richter, R., Bratislav P. Marinkovic, Paola Bolognesi, Tosic, Sanja, Tosic, S., Cartoni, Antonella, Cartoni, A., Susanna Monti, Avaldi, L.   +38 more
core   +1 more source

EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.

Vitae, 2010
In this work we realized and experimental and theoretical study of the N-alkylation of nitroimidazoles.The N-alkyl-2-methyl-nitroimidazoles correspond to biologically active molecules, obtained by reactionof 2-methyl-5-nitroimidazole and different alkyl ...
Constain SALAMANCA M., William TIZNADO V., Paula JARAMILLO G.   +2 more
doaj  

MICROBIAL OXIDATION OF AMINOIMIDAZOLES TO NITROIMIDAZOLES

The Journal of Antibiotics, 1968
The structural requirements for the microbial transformation of 2-aminoimidazoles to 2-nitroimidazoles by Streptomyces strain LE/3342 have been investigated. Substrates carrying an alkyl group in position 4 (or 5) were oxidized, the efficiency decreasing with the increase of the length of the chain.
C C, Lancini, E, Lazzari, C, Sartori
openaire   +3 more sources

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source