Results 61 to 70 of about 13,366 (181)

Nitroimidazoles for imaging hypoxic myocardium

Journal of Nuclear Cardiology, 1995
A series of radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic tissue. Myocardium with an intracellular pO2 < 3 mm Hg (about 25% of normal), which has lost its contractile ability but
H W, Strauss, A, Nunn, K, Linder
openaire   +2 more sources

EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.

Vitae, 2010
In this work we realized and experimental and theoretical study of the N-alkylation of nitroimidazoles.The N-alkyl-2-methyl-nitroimidazoles correspond to biologically active molecules, obtained by reactionof 2-methyl-5-nitroimidazole and different alkyl ...
Constain SALAMANCA M., William TIZNADO V., Paula JARAMILLO G.   +2 more
doaj  

2-Chloro-N-[(4-chlorophenyl)(phenyl)methyl]-N-[2-(4-nitro-1H-imidazol-1-yl)ethyl]ethanamine

Acta Crystallographica Section E, 2011
In the title compound, C20H20Cl2N4O2, the nitroimidazole ring makes dihedral angles of 17.00&#8197;(1) and 60.45&#8197;(11)&#176; with the phenyl and chlorophenyl rings, respectively. The three-coordinate N atom connected to two methylene and
Wen-Tai Zhang, Cheng-He Zhou, Qing-Gang Ji   +2 more
doaj   +1 more source

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

Frontiers in Chemical Biology
In the last 60 years, the broad spectrum of activity of nitroimidazole derivatives against anaerobic bacteria, parasites, and protozoa has permitted their use as the first choice of treatment for many infectious diseases.
Walter Fugarolas, Lorena Reyes-Carmona, Bruno Landeros-Rivera, Argelia Almaguer-Flores, Norah Barba-Behrens   +4 more
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Structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles

Heterocyclic Communications
As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted.
Paoli-Lombardo Romain, Primas Nicolas, Hutter Sébastien, Castera-Ducros Caroline, Jacquet Inès, Verhaeghe Pierre, Azas Nadine, Rathelot Pascal, Vanelle Patrice   +8 more
doaj   +1 more source

Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

Future Pharmacology
Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez, Edgar López-López, Catalina Soriano-Correa, Carolina Barrientos-Salcedo   +3 more
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CRISPR Screening and Comparative LC‐MS Analysis Identify Genes Mediating Efficacy of Delamanid and Pretomanid against Mycobacterium tuberculosis

Advanced Science
Tuberculosis (TB), the leading cause of death from bacterial infections worldwide, results from infection with Mycobacterium tuberculosis (Mtb). The antitubercular agents delamanid (DLM) and pretomanid (PMD) are nitroimidazole prodrugs that require ...
Mei‐Yi Yan, Haifeng Li, Yun‐Mo Qu, Si‐Shang Li, Dandan Zheng, Xiao‐Peng Guo, Zhaojun Wu, Jie Lu, Yu Pang, Weimin Li, Jian Yang, Lingjun Zhan, Yi‐Cheng Sun   +12 more
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NITROIMIDAZOLES VII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACT I V I T I E S OF 4 - S U B S T I T U T E D - 2 - TWIAZOLYLHYDRAZONES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3).
doaj  

Exploring Geometrical, Electronic and Spectroscopic Properties of 2-Nitroimidazole-Based Radiopharmaceuticals via Computational Chemistry Methods

Molecules
Tumor hypoxia plays an important role in the clinical management and treatment planning of various cancers. The use of 2-nitroimidazole-based radiopharmaceuticals has been the most successful for positron emission tomography (PET) and single photon ...
George Crișan, Ștefan Stan, Vasile Chiș   +2 more
doaj   +1 more source

NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as ...
doaj