Results 41 to 50 of about 19,687 (231)

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Synthesis of N-7-Substituted Purines from Imidazole Precursors

Molecules, 1999
Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj   +1 more source

Synthesis and Preliminary Evaluation of a Novel 18F-Labeled 2-Nitroimidazole Derivative for Hypoxia Imaging

Frontiers in Oncology, 2021
ObjectiveHypoxia is prevalent in tumors and plays a pivotal role in resistance to chemoradiotherapy. 18F-MISO (18F-labeled fluoromisonidazole) is currently the preferred choice of PET hypoxia tracers in clinical practice, but has severe disadvantages ...
Jing Lu, Jing Lu, Chi Zhang, Xi Yang, Xi Yang, Xi-Juan Yao, Qun Zhang, Xin-Chen Sun   +7 more
doaj   +1 more source

Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]

, 2007
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Keigo Endo, Masahiro Hosaka, Seiji Tobita, Shaojuan Zhang, Toshitada Yoshihara, Toshiyuki Takeuchi, Yasuhiko Iida   +6 more
core   +1 more source

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in helicobacter pylori infection [PDF]

, 2017
In this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in Helicobacter pylori (Hp) eradication, as well as the updated treatment strategies for this infection.
De Angelis, Massimiliano, Mascellino, Maria Teresa, Oliva, Alessandra, Porowska, Barbara   +3 more
core   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy

Acta Pharmaceutica Sinica B, 2023
Metastasis accounts for 90% of breast cancer deaths, where the lethality could be attributed to the poor drug accumulation at the metastatic loci. The tolerance to chemotherapy induced by breast cancer stem cells (BCSCs) and their particular redox ...
Yongchao Chu, Yifan Luo, Boyu Su, Chao Li, Qin Guo, Yiwen Zhang, Peixin Liu, Hongyi Chen, Zhenhao Zhao, Zheng Zhou, Yu Wang, Chen Jiang, Tao Sun   +12 more
doaj   +1 more source

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance. [PDF]

, 2018
Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa.
Ahmad, SM, Akre, Samir, Huda, M Nazmul, Liu, Jinxin, Maldonado-Gomez, Maria X, Mills, David A, Stephensen, Charles B, Taft, Diana H   +7 more
core   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source