Results 41 to 50 of about 2,788 (166)

Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Redox Biology, 2021
Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts.
Faisal Bin Rashed, Alexandru Cezar Stoica, Dawn MacDonald, Hassan El-Saidi, Carolynne Ricardo, Bhumi Bhatt, Jack Moore, Diana Diaz-Dussan, Nirilanto Ramamonjisoa, Yvonne Mowery, Sambasivarao Damaraju, Richard Fahlman, Piyush Kumar, Michael Weinfeld   +13 more
doaj   +1 more source

Autogenous Demineralized Dentin Graft–Based Strategies With or Without I‐PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
This randomized controlled trial evaluated the efficacy of demineralized dentin graft (DDG) combined with injectable platelet‐rich fibrin (I‐PRF) and metronidazole (MTZ) versus DDG with or without I‐PRF in alveolar ridge preservation (ARP) of infected extraction sockets.
Mohamed Talaat Elbehwashy, Manal Mohamed Hosny, Ahmed Elfana, Heba Ahmed Saleh, Karim Fawzy El‐Sayed   +4 more
wiley   +1 more source

Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on Trypanosoma cruzi and Leishmania donovani

Molecules
The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole 18–23 based on the concepts of molecular repositioning and hybridization.
Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris   +7 more
doaj   +1 more source

The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

Scientia Pharmaceutica, 2018
Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells.
Justyna Żwawiak, Lucjusz Zaprutko
doaj   +1 more source

68Ga‐nitroimidazole PET/CT imaging of hypoxia in tuberculosis: A case series

Journal of Medical Radiation Sciences, 2022
Tuberculosis (TB) lesions in humans have been proven to be severely hypoxic with hypoxia leading to latency and dormancy of disease. Dormant TB lesions become less susceptible to standard TB treatment regimens with varying responses to treatment but may ...
Philippa L Bresser, Janet Reed, Mike M Sathekge, Mariza Vorster   +3 more
doaj   +1 more source

2-(3-Bromophenyl)imidazo[2,1-b]oxazole

Molbank, 2023
The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole.
Ángel Cores, Mercedes Villacampa, J. Carlos Menéndez   +2 more
doaj   +1 more source

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

, 2018
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio- immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers.
Ralph J. Stevenson, Frederik B. Pruijn, Way Wua Wong, Robert F. Anderson, Qi, W, Stephen M. F. Jamieson, Muriel Bonnet, Wang, J, Bonnet, M, Lydia P. Liew, Kevin O. Hicks, Cho Rong Hong, Avik Shome, Wen Qi, Yongchuan Gu, Michael P. Hay, William R. Wilson, Jingli Wang, Hicks, KO, Liew, LP, Gu, Y, Wong, WW, Stevenson, RJ, Hay, MP, Anderson, RF, Wilson, WR, Hong, CR, Pruijn, FB, Jamieson, SMF, Shome, A   +29 more
core   +1 more source

Determination of antibiotics in bean sprouts by UHPLC-MS/ MS-internal standard method

Shanghai yufang yixue
ObjectiveTo establish an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-internal standard method for the simultaneous determination of 59 antibiotics, including quinolones, sulfonamides, tetracyclines, macrolides and ...
ZHANG Xiaoyi, ZHENG Sanyan, ZHANG Xiuyao, LI Ruifen, YANG Shuran   +4 more
doaj   +1 more source

Synthesis and Preliminary Evaluation of a Novel 18F-Labeled 2-Nitroimidazole Derivative for Hypoxia Imaging

Frontiers in Oncology, 2021
ObjectiveHypoxia is prevalent in tumors and plays a pivotal role in resistance to chemoradiotherapy. 18F-MISO (18F-labeled fluoromisonidazole) is currently the preferred choice of PET hypoxia tracers in clinical practice, but has severe disadvantages ...
Jing Lu, Jing Lu, Chi Zhang, Xi Yang, Xi Yang, Xi-Juan Yao, Qun Zhang, Xin-Chen Sun   +7 more
doaj   +1 more source

Structure-enabled enhancement of potency in a metronidazole–benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole

Frontiers in Pharmacology
Benznidazole (1) remains the primary antiparasitic drug used clinically for Chagas disease, underscoring the need to discover novel treatments targeting Trypanosoma cruzi (T. cruzi) infection.
Afonso Santine M. M. Velez, Otávio Augusto Chaves, Otávio Augusto Chaves, Telma Costa, Carlos Serpa, Joyce de Meyrelles Borges, Célio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Marco Edilson Freire Lima   +8 more
doaj   +1 more source