Results 21 to 30 of about 15,048 (225)

Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

Molecules, 2020
Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and ...
Robert Czarnomysy, Dominika Radomska, Anna Muszyńska, Justyna Magdalena Hermanowicz, Izabela Prokop, Anna Bielawska, Krzysztof Bielawski   +6 more
doaj   +1 more source

Nitroimidazole Derivative Antimicrobial Drugs and Liver Injury

, 2023
Nitroimidazole derivative drugs have been widely used in clinical practice for many years. Metronidazole and ornidazole are nitroimidazole derivative antimicrobial drugs commonly used in treatment of various infections caused by anaerobic bacteria and ...
Uğur Balaban, Emre Kara, Kara, Emre, İnkaya, Ahmet Çağkan, Ahmet Çağkan İnkaya, Balaban, Uğur   +5 more
core   +1 more source

N-[1-(2-Chlorophenyl)-2-{1-methyl-5-nitro-4-[(phenylsulfonyl)methyl]-1H-imidazol-2-yl}ethyl]-4-methylbenzenesulfonamide

Molbank, 2023
In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able to generate for the first time a stable carbanion in position 2 of the 5-nitroimidazole scaffold.
Romain Paoli-Lombardo, Nicolas Primas, Caroline Castera-Ducros, Inès Jacquet, Pascal Rathelot, Patrice Vanelle   +5 more
doaj   +1 more source

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2018
An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li, Yuebin Ke, Yingyu Wang, Chengfei Wang, Dongyang Ye, Xue Hu, Lan Zhou, Xi Xia   +7 more
doaj   +1 more source

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

SynOpen, 2017
The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj   +1 more source

Design and Synthesis of Vandetanib Derivatives Containing Nitroimidazole Groups as Tyrosine Kinase Inhibitors in Normoxia and Hypoxia

Molecules, 2016
Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a–p)) were designed and prepared via the introduction of a nitroimidazole group ...
Huiqiang Wei, Deguan Li, Xiangbo Yang, Haihua Shang, Saijun Fan, Yiliang Li, Dan Song   +6 more
doaj   +1 more source

Decomposition of nitroimidazole ions: experiment and theory [PDF]

, 2015
International audienceNitroimidazoles are important compounds with chemotherapeutic applications as antibacterial drugs or as radiosensitizers in radiotherapy. Despite their use in biological applications, little is known about the fundamental properties
O'Hair, R.A..J., Feketeová, L, Feketeova, L., Scheier, P., O'Hair, RAJ, Zavras, A, Denifl, S, Postler, J, Scheier, P, Zavras, A., O'Hair, R.A.J., Denifl, S., Postler, J.   +12 more
core   +1 more source

High-Density Energetic Materials with Low Mechanical Sensitivity and Twinning Derived from Nitroimidazole Fused Ring

Molecules
The innovative synthesis of 3,8-dibromo-2,9-dinitro-5,6-dihydrodiimidazo [1,2-a:2′,1′-c]pyrazine and 3,9-dibromo-2,10-dinitro-6,7-dihydro-5H-diimidazo [1,2-a:2′,1′-c][1,4]diazepine is described in this study.
Yaxin Liu, Meifang Lv, Guofeng Zhang, Zhen Dong, Zhiwen Ye   +4 more
doaj   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Redox Biology, 2021
Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts.
Faisal Bin Rashed, Alexandru Cezar Stoica, Dawn MacDonald, Hassan El-Saidi, Carolynne Ricardo, Bhumi Bhatt, Jack Moore, Diana Diaz-Dussan, Nirilanto Ramamonjisoa, Yvonne Mowery, Sambasivarao Damaraju, Richard Fahlman, Piyush Kumar, Michael Weinfeld   +13 more
doaj   +1 more source