Results 21 to 30 of about 2,788 (166)

Synthetic and antimicrobial studies of nitroimidazole analogues

, 1988
New 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions.
Adelaide T.O.M. Adebayo (7167011)
core   +3 more sources

Nitroimidazole Derivative Antimicrobial Drugs and Liver Injury

, 2023
Nitroimidazole derivative drugs have been widely used in clinical practice for many years. Metronidazole and ornidazole are nitroimidazole derivative antimicrobial drugs commonly used in treatment of various infections caused by anaerobic bacteria and ...
Uğur Balaban, Emre Kara, Kara, Emre, İnkaya, Ahmet Çağkan, Ahmet Çağkan İnkaya, Balaban, Uğur   +5 more
core   +1 more source

Treatment strategies for nitroimidazole-refractory giardiasis: a systematic review

, 2021
Rationale for review: Giardiasis is one of the most common human protozoal infections worldwide. First-line therapy of giardiasis includes nitroimidazole antibiotics. However, treatment failure with nitroimidazoles is increasingly reported, with up to 45%
Bourque, Daniel L., Chen, L. H., Neumayr, Andreas, Bourque, D. L., Libman, Michael, Libman, M., Chen, Lin H., Neumayr, A., Michael Libman, Lin H Chen, Andreas Neumayr, Daniel L Bourque   +11 more
core   +1 more source

Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds

Frontiers in Chemistry, 2019
Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli, Jacopo Chiarinelli, Anna Rita Casavola, Mattea Carmen Castrovilli, Paola Bolognesi, Antonella Cartoni, Antonella Cartoni, Feng Wang, R. Richter, Daniele Catone, Sanja Tosic, Bratislav P. Marinkovic, Lorenzo Avaldi   +12 more
doaj   +1 more source

Prevalence of Nitroimidazole-Refractory Giardiasis Acquired in Different World Regions, Sweden, 2008–2020

Emerging Infectious Diseases
Treatment-refractory giardiasis is an emerging clinical problem. Of 4,285 giardiasis cases identified during 2008–2020 in Stockholm, Sweden, 102 (2.4%) were nitroimidazole refractory. Among cases acquired in India, the percentage was high (64/545 [12%])
Karin A. Ydsten, Joanna Nederby Öhd, Urban Hellgren, Hilmir Asgeirsson   +3 more
doaj   +1 more source

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2018
An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li, Yuebin Ke, Yingyu Wang, Chengfei Wang, Dongyang Ye, Xue Hu, Lan Zhou, Xi Xia   +7 more
doaj   +1 more source

Decomposition of nitroimidazole ions: experiment and theory [PDF]

, 2015
International audienceNitroimidazoles are important compounds with chemotherapeutic applications as antibacterial drugs or as radiosensitizers in radiotherapy. Despite their use in biological applications, little is known about the fundamental properties
O'Hair, R.A..J., Feketeová, L, Feketeova, L., Scheier, P., O'Hair, RAJ, Zavras, A, Denifl, S, Postler, J, Scheier, P, Zavras, A., O'Hair, R.A.J., Denifl, S., Postler, J.   +12 more
core   +1 more source

High-Density Energetic Materials with Low Mechanical Sensitivity and Twinning Derived from Nitroimidazole Fused Ring

Molecules
The innovative synthesis of 3,8-dibromo-2,9-dinitro-5,6-dihydrodiimidazo [1,2-a:2′,1′-c]pyrazine and 3,9-dibromo-2,10-dinitro-6,7-dihydro-5H-diimidazo [1,2-a:2′,1′-c][1,4]diazepine is described in this study.
Yaxin Liu, Meifang Lv, Guofeng Zhang, Zhen Dong, Zhiwen Ye   +4 more
doaj   +1 more source

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

SynOpen, 2017
The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj   +1 more source

Nitroimidazole - albendazole combination therapy, quinacrine use, and risk factors in nitroimidazole-refractory giardiasis: a prospective multicentre observational study

BMC Infectious Diseases
Background Nitroimidazole-refractory giardiasis is an increasing problem. We present data on efficacy of a treatment ladder and on clinical characteristics and assemblage types in nitroimidazole-refractory giardiasis.
Kristine Mørch, Peter Chiodini, Laura Nabarro, Raisa Hannula, Andreas Neumayr, Christel Gill Haanshuus, Christina Saghaug, Bjørn Blomberg, Frank Olav Dahler Pettersen, Helene Heitmann Sandnes, Kurt Hanevik, Nina Langeland   +11 more
doaj   +1 more source