Results 21 to 30 of about 19,687 (231)

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2018
An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li, Yuebin Ke, Yingyu Wang, Chengfei Wang, Dongyang Ye, Xue Hu, Lan Zhou, Xi Xia   +7 more
doaj   +1 more source

Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria

Molecules, 2020
The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades.
Zhijun Zhuang, Dawei Wan, Jun Ding, Shijie He, Qian Zhang, Xiaomei Wang, Ying Yuan, Yu Lu, Charles Z. Ding, Anthony Simon Lynch, Anna M. Upton, Christopher B. Cooper, William A. Denny, Zhenkun Ma   +13 more
doaj   +1 more source

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

SynOpen, 2017
The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj   +1 more source

Design and Synthesis of Vandetanib Derivatives Containing Nitroimidazole Groups as Tyrosine Kinase Inhibitors in Normoxia and Hypoxia

Molecules, 2016
Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a–p)) were designed and prepared via the introduction of a nitroimidazole group ...
Huiqiang Wei, Deguan Li, Xiangbo Yang, Haihua Shang, Saijun Fan, Yiliang Li, Dan Song   +6 more
doaj   +1 more source

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2015
OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew, Fairlamb, Alan, Foth, Bernado J., Kelner, Anna, Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +3 more sources

Antiamoebic Properties of the Actinomycete Metabolites Echinomycin A and Tirandamycin A [PDF]

, 2012
Entamoeba histolytica infects 50 million people per year, causing 100,000 deaths worldwide. The primary treatment for amoebiasis is metronidazole. However, increased pathogen resistance combined with the drug’s toxic side effects encourages a search for ...
Espinosa, Avelina, Rowley, David C., Ryke, Erica, Socha, Aaron M.   +3 more
core   +3 more sources

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis [PDF]

, 2018
Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a resurgence in recent years. Here we review the current status of monocyclic and bicyclic nitroheterocyclic compounds as existing or potential new treatments for ...
Alan H. Fairlamb, Alliance T.B., Altcheh J., Andrade H.M., Andrade S.G., Andrade S.G., Andrews K.T., Ang C.W., Araldi R.P., Aubé J., Bahia M.T., Bahia M.T., Balasubramanian B., Barreto-Bergter E., Berriman M., Bisser S., Blumenstiel K., Boiani M., Brener Z., Bruhn D.F., Bustamante J.M., Campos M.C., Campos M.C., Chung M.C., Collins A.R., Darsaud A., de Andrade A.L., Deavall D.G., Dikhit M.R., Docampo R., Docampo R., Docampo R., Dodd M.C., Dogra M., El-Sayed N.M., Enanga B., Eperon G., Fabbro D.L., Fairlamb A.H., Fairlamb A.H., Fairlamb A.H., Fernández M.L., Ferreira R.C., Filardi L.S., Fonseca-Berzal C., Garavaglia P.A., Goijman S.G., Gupta S., Gurumurthy M., Hall B.S., Hall B.S., Hayashi M., Henderson G.B., Henderson G.B., Henriques C., Ivens A.C., Jacobs R.T., Janssens P.G., Jeganathan S., Jennings F.W., Kaiser M., Kubata B.K., Lewis M.D., Lewis M.D., Lewis M.D., Likeufack A.C.L., Maina N., Makarov V., Marin-Neto J.A., Marin-Neto J.A., Matsumoto M., Maya J.D., Mejia A.M., Mejía-Jaramillo A.M., Mesu V.K.B.K., Miura K., Moens F., Molina I., Moreno M., Moreno S.N.J., Morillo C.A., Morillo C.A., Mortelmans K., Mukherjee T., Mukkavilli R., Murta S.M., Murta S.M.F., Murta S.M.F., Neal R.A., Nesslany F., Nogoceke E., Nogueira F.B., Nogueira F.B., Olmo F., Panicucci R., Papadopoulou M.V., Papadopoulou M.V., Papadopoulou M.V., Patterson S., Patterson S., Patterson S., Portal P., Priotto G., Priotto G., Pépin J., Pépin J., Raether W., Repetto Y., Rodriques Coura J., Romero A.H., Ryan N.J., Sasahara K., Shimokawa Y., Singh R., Smith D.A., Sokolova A.Y., Stephen Patterson, Stover C.K., Stuart K., Tarleton R.L., Tarral A., Temperton N.J., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Torreele E., Trochine A., Trochine A., Trunz B.B., Tweats D., Urbina J.A., Viodé C., Walsh J.S., Wilkinson S.R., Winkelmann E., Wyllie S., Wyllie S., Wyllie S., Wyllie S., Zhou L.   +141 more
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Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents. [PDF]

, 2015
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents.
Alsford S., Andriani G., Andriani G., Baker N., Benjamín Aguilera-Venegas, Bern C., Buchanan-Kilbey G., Diniz L. d. F., Eric Chatelain, Fabbro D. L., Galina I. Lepesheva, Gautret P., Hall B. S., Hall B. S., Hargrove T. Y., Howard S. Rosenzweig, Jean-Robert Ioset, Keenan M., Lepesheva G. I., Lepesheva G. I., Lepesheva G. I., Lepesheva G. I., Leslie M., Marcel Kaiser, Maria V. Papadopoulou, Molina I., Molyneux D. H., Moraes C. B., Nwaka S., Orhan I., Papadopoulou M. V., Papadopoulou M. V., Papadopoulou M. V., Papadopoulou M. V., Rassi A., Shane R. Wilkinson, Stewart B. H., Urbina J. A., Urbina J. A., Villalta F., Wilkinson S. R., Wilkinson S. R., William D. Bloomer   +42 more
core   +3 more sources

High-Density Energetic Materials with Low Mechanical Sensitivity and Twinning Derived from Nitroimidazole Fused Ring

Molecules
The innovative synthesis of 3,8-dibromo-2,9-dinitro-5,6-dihydrodiimidazo [1,2-a:2′,1′-c]pyrazine and 3,9-dibromo-2,10-dinitro-6,7-dihydro-5H-diimidazo [1,2-a:2′,1′-c][1,4]diazepine is described in this study.
Yaxin Liu, Meifang Lv, Guofeng Zhang, Zhen Dong, Zhiwen Ye   +4 more
doaj   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj