Results 31 to 40 of about 2,788 (166)

Design and Synthesis of Vandetanib Derivatives Containing Nitroimidazole Groups as Tyrosine Kinase Inhibitors in Normoxia and Hypoxia

Molecules, 2016
Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a–p)) were designed and prepared via the introduction of a nitroimidazole group ...
Huiqiang Wei, Deguan Li, Xiangbo Yang, Haihua Shang, Saijun Fan, Yiliang Li, Dan Song   +6 more
doaj   +1 more source

Antibiotic residues in poultry‐derived foods and associated human health risks: a systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Antibiotic residues in poultry‐derived foods remain a food‐safety concern because of their implications for regulatory compliance, antimicrobial stewardship, and consumer exposure. This review synthesized evidence published between 2016 and April 2026 on the occurrence of antibiotic residues in poultry‐derived foods, analytical approaches ...
Ana Clara Nogueira Alves, Cristiane Cunha Guimarães, Tiago Cabral Nóbrega, Adriano Teixeira de Oliveira   +3 more
wiley   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core  

Studies on some novel nitroimidazole-polyamine drug conjugates.

, 1996
This thesis is a study of the synthesis of various polyamine-drug conjugates, the evaluation of their abilities to protect DNA solutions from the effects of radiation and their abilities to act as substrates for a cellular polyamine uptake system ...
Adam Qaiyoum. Siddiqui (7673846)
core   +5 more sources

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

2‐Nitroimidazole Based PET Tracers: Development of a General Synthetic Approach and Fluorination Methodology

, 2023
2-Nitroimidazole based PET tracers are widely used for non-invasive hypoxic tumor diagnosis. In this context, we report here a general method based on a central Mitsunobu reaction to easily access 2-nitroimidazole precursors. Optimization of fluorination
Vincent, Stéphane, Vincent Tadino, Xavier Maes, Nicolas Maindron, Tadino, Vincent, Rzeigui, Maha, Kévin Renault, Maindron, Nicolas, Joyard, Yoann, Maha Rzeigui, Stéphane Vincent, Horion, Romain, Renault, Kévin, Romain Horion, Maes, Xavier, Yoann Joyard   +15 more
core   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source

Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers

, 2014
A novel class of nitroimidazole alkylsulfonamides have been prepared and evaluated as hypoxia-selective cytotoxins and radiosensitisers. The sulfonamide side chain markedly influences the physicochemical properties of the analogues: lowering aqueous ...
Hicks, KO, Pruijn, FB, Wang, J, Bonnet, M, Hay, MP, Anderson, RF, Wilson, WR, Gu, Y, Hong, CR   +8 more
core   +1 more source