Results 31 to 40 of about 13,366 (181)

Remote‐Controlled Release of Nitric Oxide by Plasmonic Waveguide Coated With Metal–Organic Frameworks

Small, EarlyView.
Remote‐controlled intracellular delivery is achieved using a plasmonic waveguide coated with a photoresponsive NO‐releasing MOF. Surface plasmon polariton propagation remotely induces photocleavage and localized nitric oxide release in a target single live cell without direct light exposure, while biological relevance is demonstrated through transient ...
Tomoko Inose, Javier Lopez‐Cabrelles, Javier Troyano, Shun Tokuda, Elí Sánchez‐González, Nobuaki Takahashi, Yasuo Mori, Kenji Hirai, Hiroshi Uji‐i, Shuhei Furukawa   +9 more
wiley   +1 more source

Synthesis of N-7-Substituted Purines from Imidazole Precursors

Molecules, 1999
Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj   +1 more source

2-(3-Bromophenyl)imidazo[2,1-b]oxazole

Molbank, 2023
The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole.
Ángel Cores, Mercedes Villacampa, J. Carlos Menéndez   +2 more
doaj   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on Trypanosoma cruzi and Leishmania donovani

Molecules
The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole 18–23 based on the concepts of molecular repositioning and hybridization.
Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris   +7 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Determination of antibiotics in bean sprouts by UHPLC-MS/ MS-internal standard method

Shanghai yufang yixue
ObjectiveTo establish an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-internal standard method for the simultaneous determination of 59 antibiotics, including quinolones, sulfonamides, tetracyclines, macrolides and ...
ZHANG Xiaoyi, ZHENG Sanyan, ZHANG Xiuyao, LI Ruifen, YANG Shuran   +4 more
doaj   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy

Acta Pharmaceutica Sinica B, 2023
Metastasis accounts for 90% of breast cancer deaths, where the lethality could be attributed to the poor drug accumulation at the metastatic loci. The tolerance to chemotherapy induced by breast cancer stem cells (BCSCs) and their particular redox ...
Yongchao Chu, Yifan Luo, Boyu Su, Chao Li, Qin Guo, Yiwen Zhang, Peixin Liu, Hongyi Chen, Zhenhao Zhao, Zheng Zhou, Yu Wang, Chen Jiang, Tao Sun   +12 more
doaj   +1 more source

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source