Results 11 to 20 of about 2,788 (166)

Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria

Molecules, 2020
The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades.
Zhijun Zhuang, Dawei Wan, Jun Ding, Shijie He, Qian Zhang, Xiaomei Wang, Ying Yuan, Yu Lu, Charles Z. Ding, Anthony Simon Lynch, Anna M. Upton, Christopher B. Cooper, William A. Denny, Zhenkun Ma   +13 more
doaj   +2 more sources

Nitroimidazole-induced chronic hepatitis

European Journal of Gastroenterology & Hepatology, 2001
Drug-induced chronic hepatitis is a rare pathological condition. There is no reported case with chronic hepatitis secondary to nitroimidazole use. We report a patient who developed nitroimidazole-induced chronic hepatitis following acute exacerbation of hepatitis three times after nitroimidazole use.
Ersoz, G, Karasu, Z, Akarca, US, Gunsar, F, Yuce, G, Batur, Y   +5 more
openaire   +4 more sources

Preparation of 10B-enriched nitroimidazole derivative by click reaction as a functional drug for hypoxia-targeting boron-neutron capture therapy

Results in Chemistry
We report a novel drug that can be used for the treatment of tumor hypoxic cells by boron neutron capture therapy. We attempted to modify p‑boronophenylalanine, a agent for this therapy in practical use, with a hypoxia-accumulating functional group, 2 ...
Tatsuya Ozasa, Miu Mizutani, Tatsuya Nishihara, Minoru Suzuki, Kazuhito Tanabe   +4 more
doaj   +2 more sources

In Vivo Evaluation of the Nitroimidazole-Based Thioflavin-T Derivatives as Cerebral Ischemia Markers

International Journal of Biomedical Imaging, 2007
Timely imaging and accurate interpretation of cerebral ischemia are required to identify patients who might benefit from more aggressive therapy, and nuclear medicine offers a noninvasive method for demonstrating cerebral ischemia.
Taiwei Chu, Zejun Li, Xinqi Liu, Xiangyun Wang   +3 more
doaj   +2 more sources

Fragmentation patterns of 4(5)-nitroimidazole and 1-methyl-5-nitroimidazole - The effect of the methylation [PDF]

, 2022
We present here the photofragmentation patterns of doubly ionized 4(5)-nitroimidazole and 1-methyl-5-nitroimidazole. The doubly ionized state was created by core ionizing the C 1s orbitals of the samples, rapidly followed by Auger decay.
E. Kukk, S. Granroth, K. Kooser, K. Tanzer, E. Itälä, S. Denifl   +5 more
core   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Nitroimidazole-Based Ruthenium(II) Complexes: Playing with Structural Parameters to Design Photostable and Light-Responsive Antibacterial Agents

, 2021
5-Nitroimidazole (5NIMH), chosen as a molecular model of nitroimidazole derivatives, which represent a broad-spectrum class of antimicrobials, was incorporated into the ruthenium complexes [Ru­(tpy)­(phen)­(5NIM)]­PF6 (1) and [Ru­(tpy)­(dmp)­(5NIM)]­PF6 (
Claudia Giorgi (1719847), Camilla Fagorzi, Giangaetano Pietraperzia, Barbara Valtancoli, Claudia Giorgi, Annalisa Guerri (1779556), Alessio Mengoni (619628), Alessio Mengoni, Ilaria Palchetti (698770), Gina Elena Giacomazzo (11726598), Marco Pagliai (1282797), Camilla Fagorzi (5814413), Barbara Valtancoli (1960708), Gina Elena Giacomazzo, Patrick Severin Sfragano, Luca Conti, Marco Pagliai, Giangaetano Pietraperzia (1736587), Ilaria Palchetti, Annalisa Guerri, Luca Conti (5872802), Patrick Severin Sfragano (11726601)   +21 more
core   +1 more source

Chemosensitization by lipophilic nitroimidazoles [PDF]

British Journal of Cancer, 1983
We have carried out experiments to determine the response of tumours and normal tissues in the C3H mouse to the combination of lipophilic nitroimidazoles and CCNU, cyclophosphamide or melphalan. The nitroimidazoles studied were Ro 07-1902 (1902) and benznidazole (Ro 07-1051, BENZO). Maximum enhancement of CCNU response in the KHT sarcoma by 2.5 mmol kg-
P R, Twentyman, P, Workman
openaire   +2 more sources

The Role of Nitroreductases in Resistance to Nitroimidazoles [PDF]

Biology, 2021
Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of ...
Carol Thomas, Christopher D. Gwenin
openaire   +3 more sources