Results 51 to 60 of about 15,048 (225)

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

, 2018
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio- immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers.
Ralph J. Stevenson, Frederik B. Pruijn, Pruijn, Frederik, Way Wua Wong, Robert F. Anderson, Liew, Lydia, Shome, Avik, Gu, Yongchuan, Hicks, Kevin, Stevenson, Ralph, Jamieson, Stephen, Qi, W, Stephen M. F. Jamieson, Muriel Bonnet, Wang, J, Bonnet, M, Wong, Way, Wilson, William, Lydia P. Liew, Kevin O. Hicks, Hay, Michael, Cho Rong Hong, Anderson, Robert, Avik Shome, Wen Qi, Yongchuan Gu, Michael P. Hay, William R. Wilson, Jingli Wang, Hong, Cho   +29 more
core   +1 more source

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

In vitro evaluation and in vivo efficacy of nitroimidazole‑sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana

, 2021
The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela.
Charris, Jaime E., Oviedo, Henry J., Rodríguez, Noris M., Charris, Jaime, Blanco, Zuleima, Mijares, Michael R., Ramírez, Hegira, Fernández Moreira, Esteban   +7 more
core   +1 more source

Synthetic and antimicrobial studies of nitroimidazole analogues

, 1988
New 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions.
Adelaide T.O.M. Adebayo (7167011)
core   +1 more source

Michael-type addition of azoles of broad-scale acidity to methyl acrylate

Beilstein Journal of Organic Chemistry, 2011
An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-
Sławomir Boncel, Kinga Saletra, Barbara Hefczyc, Krzysztof Z. Walczak   +3 more
doaj   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia.

, 2016
Hypoxia, or low oxygen concentration, is a key factor promoting tumor progression and angiogenesis and resistance of cancer to radiotherapy and chemotherapy.
Yoichi Shimizu, Kenichi Higashino, Songji Zhao, Yoshito Numata, Songji Zhao (458333), Yukiko Masaki (3140088), Yoichi Shimizu (2580616), Yukiko Masaki, Fei Feng (427513), Yuji Kuge, Yoshito Numata (2334313), Takeshi Yoshioka (2580622), Yuji Kuge (458337), Takeshi Yoshioka, Fei Feng, Kenichi Higashino (1557556)   +15 more
core   +1 more source

Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on Trypanosoma cruzi and Leishmania donovani

Molecules
The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole 18–23 based on the concepts of molecular repositioning and hybridization.
Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris   +7 more
doaj   +1 more source

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source

Nitroimidazole resistance in Helicobacter pylori

, 2000
The efficacy of a nitroimidazole-containing regimen for the treatment of Helicobacter pylori infection is decreased by nitroimidazole resistance. Nitroimidazoles are metabolized by H.
Van der Wouden, EJ, Kleibeuker, JH, Thijs, JC, Van Zwet, AA   +3 more
core   +1 more source