Results 51 to 60 of about 2,788 (166)
Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1998 The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj
Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj +1 more source
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion
Drug Delivery, 2023 Hepatocellular carcinoma (HCC) is a malignant tumor leading cancer-associated high mortality worldwide. Unfortunately, the most commonly used drug therapeutics not only lack of target ability and efficiency, but also exhibit severe systemic toxicity to ...
Congyi Zhang +8 more
doaj +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Novel and emerging antimicrobial strategies in the management of oral infections
Periodontology 2000, EarlyView.Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley +1 more source
Acta Pharmaceutica Sinica B, 2023 Metastasis accounts for 90% of breast cancer deaths, where the lethality could be attributed to the poor drug accumulation at the metastatic loci. The tolerance to chemotherapy induced by breast cancer stem cells (BCSCs) and their particular redox ...
Yongchao Chu +12 more
doaj +1 more source
Ruthenium nitroimidazole complexes as radiosensitizers
, 1988 Local control of tumours by radiotherapy may fail due to the presence of regions of hypoxic cells. Radiosensitizers, such as nitroimidazoles, enhance killing of the resistant cells by ionizing radiation. However, dose limiting side-effects have prevented
Chan, Peter Ka-Lin
core +1 more source
Silent Contaminants: Antibiotic‐Resistant Bacteria in Food Systems
MicrobiologyOpen, Volume 15, Issue 6, December 2026.This graphical abstract illustrates the “farm‐to‐fork” cycle of antibiotic resistance, highlighting how antibiotic use promotes resistant bacteria that spread through animals, crops, food, and humans, emphasizing the interconnected nature of antimicrobial resistance and the need for integrated One Health strategies to mitigate its global impact ...
Răzvan Odocheanu +3 more
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 11, November 2026.The broad ecological range of Salmonella enterica serotype Typhimurium is associated with dynamic gain and loss of accessory genes, including plasmid‐associated antimicrobial resistance (AMR) genes, along with positive selection on core genes, potentially contributing to its differential adaptation across food animal and non‐food animal reservoirs ...
Leela Ohri +8 more
wiley +1 more source
Michael-type addition of azoles of broad-scale acidity to methyl acrylate
Beilstein Journal of Organic Chemistry, 2011 An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-
Sławomir Boncel +3 more
doaj +1 more source