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Current Issues in Molecular BiologyBackground: Tumor hypoxia is a major determinant of radioresistance, limiting oxygen-mediated fixation of radiation-induced DNA damage and promoting metabolic adaptation, tumor aggressiveness, and treatment failure. Nitroimidazole derivatives and related
Enrico Rosa +9 more
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Acyclonucleosides of 2-nitroimidazole and uses as diagnostic and therapeutic agents [PDF]
, 1990 An acyclonucleoside of nitroimidazole having the ability to specifically bind to tumor cells and useful for therapy, chemotherapy, imaging and radiosensitizing the tumor ...
Hasan, Ahmad, Srivastava, Prem C.
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Heterocyclic CommunicationsAs part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted.
Paoli-Lombardo Romain +8 more
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The determination of nitroimidazole residues in fish and fish products [PDF]
, 2011 xvii, 278 leaves : ill. ; 29 cm.Includes abstract.Includes bibliographical references (leaves 156-164).A method was developed and validated for the determination of nitroimidazoles (NIs) including 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI ...
Watson, Lynn
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Advanced ScienceTuberculosis (TB), the leading cause of death from bacterial infections worldwide, results from infection with Mycobacterium tuberculosis (Mtb). The antitubercular agents delamanid (DLM) and pretomanid (PMD) are nitroimidazole prodrugs that require ...
Mei‐Yi Yan +12 more
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Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review
Future PharmacologyNeglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez +3 more
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NITROIMIDAZOLES VII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACT I V I T I E S OF 4 - S U B S T I T U T E D - 2 - TWIAZOLYLHYDRAZONES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1990 Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3).
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MoleculesTumor hypoxia plays an important role in the clinical management and treatment planning of various cancers. The use of 2-nitroimidazole-based radiopharmaceuticals has been the most successful for positron emission tomography (PET) and single photon ...
George Crișan +2 more
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Some nitroimidazole derivatives as possible antibacterial agents
, 1993 PubMed: 8323675In this study, six 1-[2(benzazol-2-yl)thioethy-2-methyl-5-nitroimidazole derivatives were synthesized. Antibacterial activities of the compounds obtained were examined and it was found that they are effective against aerobe ...
Kiraz, N., Demirayak, Şeref
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NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1990 Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as ...
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