Results 101 to 110 of about 15,048 (225)

Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia

, 2012
Giardia lamblia (syn. duodenalis, intestinalis) is a globally occurring micro-aerophilic human parasite that causes gastrointestinal disease. Standard treatment of G. lamblia infections is based on the 5-nitroimidazole drugs metronidazole and tinidazole.
Leitsch, David, Duchêne, Michael, Schlosser, Sarah, Burgess, Anita   +3 more
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Efficient Synthesis of DNA Containing the Guanine Oxidation-Nitration Product 5-Guanidino-4-nitroimidazole:  Generation by a Postsynthetic Substitution Reaction

, 2016
A convertible nucleoside was synthesized and used to prepare the 2‘-deoxynucleoside of 5-guanidino-4-nitroimidazole, a putative in vivo product of the reaction of peroxynitrite with guanine.
William L. Neeley (2507212), Paul T. Henderson (847604), John M. Essigmann (357654)   +2 more
core   +1 more source

METABOLISM OF A DEUTEROPORPHYRIN-NITROIMIDAZOLE ADDUCT BY GASTROINTESTINAL BACTERIA [PDF]

, 2017
This thesis characterised the activity of a previously synthesised deuteroporphyrin-nitroimidazole adduct, ‘P5’. Surprisingly, P5 stimulated the growth of the nitroimidazole-sensitive Bacteroides spp. (five strains).
Dingsdag, Simon
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Characterising the binding of 2-nitroimidazole : a proton NMR study

, 2017
Tumor hypoxia is known to limit the effectiveness of current radiotherapy treatments, and is of significant interest in oncology [1]. Conventionally, tumor hypoxia has been quantified through electrode measurements of intratumoral pO2 [2].
Wijesekera, Nadeeja (S32280), Gupta, Abhishek (R18354), Zheng, Gang (R13962), Price, William S. (R10381), Torres, Allan M. (R11665), Willis, Scott A. (R17512)   +5 more
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Long distance-S(RN)1 in nitroimidazole series favored by temperature

, 2011
International audienceNew reductive alkylating agents in 4- and 5-nitroimidazole series produce exclusively O-alkylation with nitronate anions under classical S(RN)1 conditions at room temperature.
Maxime D. Crozet, Laura Zink, Patrice Vanelle, Vanelle, Patrice, Zink, Laura, Crozet, Maxime D., Terme, Thierry, Thierry Terme   +7 more
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NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as ...
doaj  

In vivo pharmacokinetic parameters in lungs for bicyclic 4-nitroimidazole analogs.

, 2014
In vivo pharmacokinetic parameters in lungs for bicyclic 4-nitroimidazole analogs.
Mahesh Nanjundappa (619075), Meera Gurumurthy (448172), Francesca Blasco (619077), Suresh B. Lakshminarayana (619070), Clifton E. Barry III (197104), Helena I. M. Boshoff (440160), Thomas Dick (284563), Joseph Cherian (619071), Anne Goh (619073), Sindhu Ravindran (619072), Amit Nayyar (619076), Ujjini H. Manjunatha (9505), Jan Jiricek (619074), Ramandeep Singh (118586), Paul C. Ho (277896)   +14 more
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Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

, 2013
The syntheses of new nitroimidazole compounds using silicon-[ 18F]fluorine chemistry for the potential detection of tumor hypoxia are described.
Bischoff, Laurent, Bol, Vanesa, Grégoire, Vincent, Joyard, Yoann, Azzouz, Rabah, Bol, Anne, Bohn, Pierre, Papamicaël, Cyril, Bol, Vanessa, Vera, Pierre, Labar, Daniel, Levacher, Vincent   +11 more
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Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA)

Communications Biology
The antibiotic 2-nitroimidazole (2NI) or azomycin, used for treating drug-resistant tuberculosis and imaging tumor hypoxia, requires activation by bacterial nitroreductases for its antibiotic and cytotoxic effect. Mycobacterium sp.
F. Hafna Ahmed, Jian-Wei Liu, Santana Royan, Andrew C. Warden, Lygie Esquirol, Gunjan Pandey, Janet Newman, Colin Scott, Thomas S. Peat   +8 more
doaj   +1 more source

Studies on some novel nitroimidazole-polyamine drug conjugates.

, 1996
This thesis is a study of the synthesis of various polyamine-drug conjugates, the evaluation of their abilities to protect DNA solutions from the effects of radiation and their abilities to act as substrates for a cellular polyamine uptake system ...
Adam Qaiyoum. Siddiqui (7673846)
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