Results 101 to 110 of about 2,788 (166)
, 1965 A series of 1-substituted dinitropyrroles was tested for trichomonacidal activity. The shorter the substituent the greater was the in vitro activity. No relationship was found between in vivo activity and substituent length.
George W. Brown +2 more
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Characterising the binding of 2-nitroimidazole : a proton NMR study
, 2017 Tumor hypoxia is known to limit the effectiveness of current radiotherapy treatments, and is of significant interest in oncology [1]. Conventionally, tumor hypoxia has been quantified through electrode measurements of intratumoral pO2 [2].
Wijesekera, Nadeeja (S32280) +5 more
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SYNTHESIS, TENTATIVE CHARACTERISATION AND ANTIMICROBIAL ACTIVITIES OF 1-ETHYL-2-METHYL-4-NITROIMIDAZOLE-5-THIOL AND ITS DERIVATIVES [PDF]
, 2019 The study is on the synthesis, characterization and antimicrobial activities of 1-ethyl-2-methyl-4-nitroimidazole-5-thiol and its derivatives. 5-chloro-1-ethyl-2-methylimidazole (2) was synthesized by reacting N, N-diethyloxamide (1) with PCl5. Compound (
Okpara, G.E., Owolabi, B.J., Ndibe, H.C.
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, 1981 4-Nitroimidazole binding to horse heart metmyoglobin was studied as a function of pH and ionic strength. The pKa of 4- nitroimidazole was also studied as a function of ionic strength.
Taylor, Kevin C.
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The effect of bioreduction on the oncogenicity of nitroimidazoles
Biochemical Pharmacology, 1986 E J, Hall, T K, Hei
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Clinical Microbiology and Infection, 2015 Giardia intestinalis is the commonest gastrointestinal protozoal pathogen worldwide, and causes acute and chronic diarrhoea with malabsorption. First-line treatment is with a nitroimidazole, with a reported efficacy rate of 89%.
P L Chiodini
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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
Voogd, CE
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Obstetrical & Gynecological Survey, 1982
Nitroimidazoles, including metronidazole, tinidazole and ornidazole, are low molecular weight antimicrobial compounds with excellent activity against anaerobic microorganisms. These compounds are usually bactericidal at low concentrations and their spectrum of activity encompasses almost all the anaerobic bacteria and some capnophylic organisms.
F P, Tally, B, Goldin, N E, Sullivan
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Nitroimidazoles, including metronidazole, tinidazole and ornidazole, are low molecular weight antimicrobial compounds with excellent activity against anaerobic microorganisms. These compounds are usually bactericidal at low concentrations and their spectrum of activity encompasses almost all the anaerobic bacteria and some capnophylic organisms.
F P, Tally, B, Goldin, N E, Sullivan
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