Results 121 to 130 of about 2,788 (166)

Tinidazole: A nitroimidazole antiprotozoal agent

Clinical Therapeutics, 2005
Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
openaire   +2 more sources

Clinical experience with nitroimidazoles as radiosensitizers

International Journal of Radiation Oncology*Biology*Physics, 1982
Abstract Clinical experience at Mount Vernon now includes 248 patients who have been given misonidazole (Ro 07–0582) and 57 patients who have been given desmethylmisonidazole (Ro 05–9963). Work with Ro 03–8799 is now beginning. The promise of chemical agents to improve the results of the radiotherapy is dependent upon effective levels of ...
S, Dische, M I, Saunders, P, Anderson, M R, Stratford, A, Minchinton   +4 more
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The synthesis of azomycin (2-Nitroimidazole)

Experientia, 1965
La sintesi del 2-nitroimidazolo e del 1-metil-2-nitroimidazolo per diazotasione e reasione di Gattermann a partire dai corrispondenti 2-aminoimidasoli dimostra che, in determinate condizioni, questi ultimi si comportano come composti a carattere aromatico.
G C, LANCINI, E, LAZZARI
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Pharmacokinetics of Nitroimidazoles

1982
In this paper I want to try and show how a knowledge of the metabolism and pharmacokinetics of a compound helps us to understand the reasons why it may or may not satisfy the criteria desired of a particular drug. How we want a drug to behave depends on the use we have in mind for it. For example, in Fig.
T. R. Marten, R. J. Ruane, J. A. White, L. Clarke   +3 more
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Nitroimidazoles as modifiers of nitrosourea pharmacokinetics

International Journal of Radiation Oncology*Biology*Physics, 1984
We have studied the effect of a number of nitroimidazole sensitizers of varying lipophilicity on the pharmacokinetics of CCNU in mice. It was found that the effectiveness of these compounds in producing pharmacokinetic effects correlated directly with their lipophilicity, viz.
F Y, Lee, P, Workman
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1-Trityl-4-nitroimidazole

Acta Crystallographica Section C Crystal Structure Communications, 1996
X-ray analysis confirmed the configuration of the title N1-alkylated C4-nitroimidazole inhibitor. The plane of the imidazole ring, sitting on an axis of the trityl propeller, bisects the angle between two phenyl rings, while the nitro group extends over the third.
E, Skrzypczak-Jankun, R G, Kurumbail
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Radiosensitization of solid tumors by nitroimidazoles

International Journal of Radiation Oncology*Biology*Physics, 1978
Abstract Recently a new class of drugs has been identified by Adams et al. at the Gray Laboratory, which act as specific radiosensitizers of hypoxic cells. This sensitization results from their high electron affinity, and their presence at the time of irradiation abolishes the protection afforded by hypoxia.
J, Denekamp, J F, Fowler
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Cost of nitroimidazoles

Medical Journal of Australia, 1984
David Cranna, Allan J. McLean, Lisa L. Ioannides‐Demos, W. John Spicer   +3 more
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Antiparasitic nitroimidazoles. 1. 2-Styryl-5-nitroimidazoles

Journal of Medicinal Chemistry, 1972
W J, Ross, W B, Jamieson, M C, McCowen
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Safety of nitroimidazoles.

Scandinavian journal of infectious diseases. Supplementum, 1986
The nitroimidazoles used in the treatment of anaerobic infection are well-tolerated by patients. With the possible exception of neurotoxic effects associated with high dosage, signs and symptoms of toxicity are transient and disappear soon after withdrawal of treatment.
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