Results 11 to 20 of about 19,627 (213)
Chemosensitization by lipophilic nitroimidazoles [PDF]
British Journal of Cancer, 1983 We have carried out experiments to determine the response of tumours and normal tissues in the C3H mouse to the combination of lipophilic nitroimidazoles and CCNU, cyclophosphamide or melphalan. The nitroimidazoles studied were Ro 07-1902 (1902) and benznidazole (Ro 07-1051, BENZO). Maximum enhancement of CCNU response in the KHT sarcoma by 2.5 mmol kg-
P R, Twentyman, P, Workman
openaire +2 more sources
Hydrophobically modified polyelectrolytes as potential drugs reservoirs of n-alkyl-nitroimidazoles [PDF]
, 2007 Indexación: ScieloThe solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different ...
Acevedo, Betsabé +3 more
core +1 more source
Molecules, 2020 Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and ...
Robert Czarnomysy +6 more
doaj +1 more source
Predictors of Failure from Primary Therapy for Giardiasis in San Diego: A Single Institution Retrospective Review. [PDF]
, 2019 This study aimed to determine the presence of giardiasis among HIV patients in San Diego, the rate of failure of metronidazole treatment, and factors associated with treatment failure.
Debnath, Anjan +2 more
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Molbank, 2023 In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able to generate for the first time a stable carbanion in position 2 of the 5-nitroimidazole scaffold.
Romain Paoli-Lombardo +5 more
doaj +1 more source
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]
, 2015 OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew +5 more
core +3 more sources
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis. [PDF]
PLoS ONE, 2014 PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during ...
Suresh B Lakshminarayana +14 more
doaj +1 more source
Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures [PDF]
, 2003 This paper compares several published methods for clustering chemical structures, using both graph- and fingerprint-based similarity measures. The clusterings from each method were compared to determine the degree of cluster overlap. Each method was also
Blankley, C.J. +2 more
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Treatment of Giardiasis after Nonresponse to Nitroimidazole
Emerging Infectious Diseases, 2014 During January 2008–October 2013, a total of 12 cases of giardiasis at the Chaim Sheba and Shaare Zedek Medical Centers, Israel, did not respond to nitroimidazole; 83.3% were associated with travel and 33% with immunoglobulin deficiency.
Eli Schwartz +2 more
doaj +1 more source
Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds
Frontiers in Chemistry, 2019 Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli +12 more
doaj +1 more source