Results 71 to 80 of about 8,282 (214)

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa [PDF]

, 2010
Tuberculosis (TB) remains a global emergency and is responsible for 1.7 million deaths annually. Widespread global misuse of isoniazid and rifampicin over three decades has resulted in emergence of the ominous spread of multidrug-resistant TB (MDR-TB ...
Abdool Karim, Amor, Balabanova, Caminero, Centers for Disease Control and Prevention, Chan, Chiang, Chiang, Chiang, Churchyard, Dheda, Dravniece, Dubrovina, Elliott, Espinal, Espinal, Espinal, Flament-Saillour, Gandhi, Gandhi, Gandhi, Goble, Grobusch, Habeenzu, Hoek, Holtz, Holtz, Iseman, Johnson, Kehinde, Kim, Kingkaew, Korenromp, Kranzer, Lalloo, Laserson, Lienhardt, Ma, Martin, Matteelli, Meskel, Migliori, Migliori, Migliori, Migliori, Migliori, Moore, Motus, O’Donnell, Pablos-Méndez, Pai, Park, Pietzka, Pillay, Quy, Saravia, Schaaf, Schaaf, Shah, Somocurcio, Sonnenberg, Sotgiu, Torun, Umubyeyi, Wallis, WHO, WHO, WHO and IUATLD, Wright, Wright, Zumla   +70 more
core   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents

Memorias do Instituto Oswaldo Cruz
BACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10)
Ana Claudia Manoel Von Trompowsky, Taline Ramos Conde, Renata Calil Lemos, Bruna Maria CS Quaresma, Marcelly Cristina SR Pitombeira, Alcione Silva de Carvalho, Núbia Boechat, Kelly Salomão, Solange Lisboa de Castro, Helena Pereira da Silva Zamith   +9 more
doaj   +1 more source

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Molecules, 2005
Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are
Patrice Vanelle, Michel P. Crozet, Pascal George, Maxime D. Crozet   +3 more
doaj   +1 more source

A Case of Drug‐Induced Pancreatitis

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Drug‐induced pancreatitis (DIP) is a rare but important cause of acute abdominal pain, and ciprofloxacin‐associated cases are exceptionally uncommon. We report a 35‐year‐old woman with no significant medical history who developed severe epigastric pain radiating to the back, accompanied by nausea and vomiting, 3 days after initiating self ...
Muskan Shrestha, Pratick Shrestha, Adarsha Mahaseth, Abhishek Shrestha, Prabin Duwadee, Rajat K. Shah   +5 more
wiley   +1 more source

Ruptured Amoebic Liver Abscess With Empyema, Venous Thromboembolism and Bronchopleural Fistula: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Amoebiasis, a gastrointestinal infection caused by Entamoeba histolytica, is the third leading cause of mortality worldwide among parasitic infections with over 100,000 deaths annually. Apart from dysentery, it can manifest as extraintestinal disease, most commonly liver abscess, and rarely pulmonary, cardiac, and brain involvement.
Nur H. Ahnal, Siti N. Mohd Nawi, Wan S. Wan Ghazali, Alwi Muhd Besari, Hafsah Sazali, Fathin Hadi   +5 more
wiley   +1 more source

A Hypoxia‐Responsive Near‐Infrared Phosphorescence Nanoprobe for High‐Sensitive Detection of Tumor Cells and Imaging of Colorectal Cancer In Situ

Aggregate, Volume 7, Issue 1, January 2026.
We have successfully developed a hypoxia‐responsive near‐infrared phosphorescent probe, Ir‐PEG. This nanoprobe demonstrates high sensitivity, water solubility, and deep‐tissue penetration. It remains specifically activatable even in the hypoxic intestinal environment, facilitating high‐contrast imaging of orthotopic colon cancer.
Jian Chen, Huamin Lan, Sensen Zhou, Weizhi Chen, Xu Zhen, Xiqun Jiang   +5 more
wiley   +1 more source

Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety

Molecules, 2016
We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz, Fanny Mathias, Alain Gamal Giuglio-Tonolo, Thierry Terme, Patrice Vanelle   +4 more
doaj   +1 more source