Results 131 to 140 of about 1,580 (161)

The acute and chronic toxicities of nivalenol in mice

Fundamental and Applied Toxicology, 1988
In an attempt to ascertain precisely the toxic effects of nivalenol (NIV), we conducted the determination of LD50 values, and interim kills during the carcinogenic study in mice. LD50 values (mg/kg) of NIV in 6-week-old male ddY mice were determined as 38.9 (po), 7.4 (ip), 7.2 (sc), and 7.3 (iv).
J C, Ryu, K, Ohtsubo, N, Izumiyama, K, Nakamura, T, Tanaka, H, Yamamura, Y, Ueno   +6 more
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Production and Characterization of Monoclonal Antibodies to Nivalenol Tetraacetate and Their Application to Enzyme-Linked Immunoassay of Nivalenol

Biological Chemistry Hoppe-Seyler, 1990
Three monoclonal antibodies were obtained by the fusion of mouse myeloma cells with splenocytes isolated from BALB/c mice that had been immunized with 8-hydroxy-3,4,7,15-tetraacetyl-nivalenol hemiglutarate covalently bound to bovine serum albumin.
H, Ikebuchi, R, Teshima, K, Hirai, M, Sato, M, Ichinoe, T, Terao   +5 more
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Nivalenol production byFusarium poae

Mycotoxin Research, 1991
Fusarium sp. were isolated from Swedish nivalenol containing grain and tested for toxin production. OnlyF. poae, 6 of 10 isolates, produced nivalenol. Highest production (44.7 μg/g) was obtained cultured on rice during 4 week at room temperature and under near UV-light. FiveF.
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Effects of nivalenol on pregnancy and fetal development of mice

Mycotoxin Research, 1986
Nivalenol (3,4,7,15-tetrahydroxy-12,13-epoxytrichothec-9-en-8-one) was injected intraperitoneally to pregnant mice at dose levels of 0, 0.1, 0.5 or 1.5 mg/kg b.w./day on days 7-15 of gestation. The highest dose caused stillbirths after vaginal hemorrhage in six of ten animals. High embryo lethality was recorded in the 2 highest dose groups (87.8 and 48.
Y, Ito, K, Ohtsubo, K, Ishii, Y, Ueno
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Effects of nivalenol on hepatic drug-metabolizing activity in rats

Food and Chemical Toxicology, 1993
Effects of nivalenol (NIV), a trichothecene mycotoxin, on hepatic drug-metabolizing activity and aflatoxin B1 (AFB1) metabolism were investigated in male rats. In rats fed the diets containing 6-12 ppm NIV for 2 or 4 wk, decreases in initial feed uptake, terminal weight gain and organ weights were evident.
T, Yabe, H, Hashimoto, M, Sekijima, M, Degawa, Y, Hashimoto, F, Tashiro, Y, Ueno   +6 more
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Subchronic feeding studies with nivalenol in C57BL/6 mice

Food and Chemical Toxicology, 1989
Groups of ten C57BL/6CrSlc SPF mice of each sex were fed diets containing 0, 6, 12 or 30 ppm nivalenol for 4 or 12 wk. Body-weight gains of males and females were depressed, dose-dependently in the case of males. Feed consumption was also depressed.
H, Yamamura, T, Kobayashi, J C, Ryu, Y, Ueno, K, Nakamura, N, Izumiyama, K, Ohtsubo   +6 more
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The fates of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice

Toxicon, 2003
In order to investigate the comparative fates of nivalenol (NIV) and 4-acetyl derivative of NIV (fusarenon-X, FX) in mice, 3H-FX or 3H-NIV was given p.o. to mice. Radioactivity was excreted mainly via the urine in mice given 3H-FX, but mainly via the feces in mice given 3H-NIV.
Amnart, Poapolathep, Yoshiko, Sugita-Konishi, Kunio, Doi, Susumu, Kumagai   +3 more
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Immunotoxicity of nivalenol after subchronic dietary exposure to rats

Food and Chemical Toxicology, 2008
Immunobiological effects of nivalenol (NIV), a trichothecene mycotoxin produced by Fusarium nivale, were examined in male F344 rats after 90-day dietary exposure at doses of 0, 0.4, 1.5, and 6.9 mg/kg body weight/day (0, 6.25, 25 and 100 ppm, respectively) in a subchronic toxicity study.
Atsutaka, Kubosaki, Maki, Aihara, Bong Joo, Park, Yoshitsugu, Sugiura, Makoto, Shibutani, Masao, Hirose, Yoshihiko, Suzuki, Kosuke, Takatori, Yoshiko, Sugita-Konishi   +8 more
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Transepithelial transport of fusariotoxin nivalenol: Mediation of secretion by ABC transporters

Toxicology Letters, 2007
Mycotoxin nivalenol (NIV) is a natural contaminant of various cereal crops, animal feed and processed grains throughout the world. Human and animal contamination occurs mainly orally, and the toxin must traverse the intestinal epithelial barrier before inducing potential health effects.
Tep, Jonathan, Videmann, Bernadette, Mazallon, Michelle, Balleydier, Sabine, Cavret, Severine, Lecoeur, Sylvaine   +5 more
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A case report on a minor contamination of nivalenol in cereals harvested in Canada

Mycopathologia, 1988
An investigation for the occurrence of nivalenol (NIV), deoxynivalenol (DON) and zearalenone (ZEN) in cereals (ten wheat, one rye and one corn) harvested in Canada have been carried out using a procedure, which is rapid and sensitive for Fusarium mycotoxins. NIV, DON and ZEN were detected in 4, 9 and 9 out of ten wheat samples, and their average levels
T, Tanaka, A, Hasegawa, S, Yamamoto, Y, Sugiura, Y, Ueno   +4 more
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