Results 231 to 240 of about 653,368 (363)

A novel ELF4 gene variant disrupts T and NK cell function in a patient with immune thrombocytopenia (ITP). [PDF]

Inflamm Res
Kendirli PK, Erdem Ş, Kısaarslan AP, Gök V, Kayhan E, Özcan A, Dogan ME, Klein C, Ünal E, Eken A.   +9 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Primary NK/T Cell Lymphoma of the Upper Esophagus

, 2004
Sho Morita, Atsuro Seki, Noboru Hamada
openalex   +2 more sources

iPSC-derived Rejuvenated T-cell Therapy for Extranodal NK/T-cell Lymphoma, Nasal Type

, 2020
Miki Ando, Jun Ando, Tadahiro Honda, Midori Ishii, Hiromitsu Nakauchi, Norio Komatsu   +5 more
openalex   +2 more sources

Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia. [PDF]

iScience
Giorgetta S, Cortopassi F, Chanis T, Ni J, Correia MP, Sticht C, Ast V, Platten M, Cerwenka A, Stojanovic A.   +9 more
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Reduced NK cell activity and abnormal expression of CCR7 and CXCR1 by NK cells analysis in patients with DOCK8 deficiency

, 2014
Giovanna Tabellini, Sonia Caracciolo, Ornella Patrizi, Marzia Benassi, Silvia Negri, Michael G. Giacomelli, Vassilios Lougaris, Alessandro Plebani, Raffaele Badolato, Silvia Parolini   +9 more
openalex   +1 more source

NK cell adoptive transfer in acute myeloid leukemia: a systematic review and meta-analysis. [PDF]

Front Immunol
Grassi LDV, Candelaria GTP, Dias IO, Nishimoto AR, Fontão K, Moreira FMRA, de Andrade HD, Kutner JM, Hamerschlak N, De Godoy JAP, Arcuri LJ, Kerbauy LN.   +11 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Circulating and Tumor-Infiltrating Foxp3⁺ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma [PDF]

, 2011
Roujun Peng, Zhou-Feng Huang, Yi-Lan Zhang, Zhong-Yu Yuan, Yi Xia, Wen-Qi Jiang, Yi-Xin Zeng, Jiang Li   +7 more
openalex   +1 more source