Results 231 to 240 of about 316,773 (316)

Lactate-mediated NK cell dysfunction as a prognostic marker and therapeutic target in breast cancer. [PDF]

Cell Death Discov
Ielpo S, Barberini F, Gaiba A, Baronti C, Greppi M, Obino V, Ravera S, Bussola N, De Ninno A, Businaro L, Mussi V, Pomella S, Agolini E, Benvenuto M, Focaccetti C, Marcenaro E, Bei R, Barillari G, Pesce S, Cifaldi L, Melaiu O.   +20 more
europepmc   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

A novel ELF4 gene variant disrupts T and NK cell function in a patient with immune thrombocytopenia (ITP). [PDF]

Inflamm Res
Kendirli PK, Erdem Ş, Kısaarslan AP, Gök V, Kayhan E, Özcan A, Dogan ME, Klein C, Ünal E, Eken A.   +9 more
europepmc   +1 more source

NK Cells

Immunobiology, 1981
openaire   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia. [PDF]

iScience
Giorgetta S, Cortopassi F, Chanis T, Ni J, Correia MP, Sticht C, Ast V, Platten M, Cerwenka A, Stojanovic A.   +9 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

NK cell adoptive transfer in acute myeloid leukemia: a systematic review and meta-analysis. [PDF]

Front Immunol
Grassi LDV, Candelaria GTP, Dias IO, Nishimoto AR, Fontão K, Moreira FMRA, de Andrade HD, Kutner JM, Hamerschlak N, De Godoy JAP, Arcuri LJ, Kerbauy LN.   +11 more
europepmc   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source