Results 241 to 250 of about 653,368 (363)

Advancements and Challenges in Mouse Models for NK Cell-Based Cancer Immunotherapy. [PDF]

Cancers (Basel)
Vitale C, Ruiba A, Dondero A, Serra M, Tassistro A, Bottino C, Castriconi R.   +6 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Preclinical and clinical studies on CAR-NK cell therapy: latest update from 2025 ASH Annual Meeting. [PDF]

Exp Hematol Oncol
Luo H, Ding Y, Zhao X.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

NK-ACTIVATING DENDRITIC CELLS ARE ELICITED BY STIMULATION WITH TOLL-LIKE RECEPTOR 3

, 2007
Tsukasa Seya, Misako Matsumoto, Takashi Ebihara, Takashi Akazawa   +3 more
openalex   +1 more source

Mitochondrial impairment and mTORC1 signalling exhaustion define NK Cell dysfunction progression in melanoma. [PDF]

Cancer Immunol Immunother
Mylod E, Behan J, Baier D, Kelleher FC, Gardiner CM.   +4 more
europepmc   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

1137 A human-derived bacterium’s capsular polysaccharide activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy [PDF]

Allison M. Weis, Kaylyn M. Bauer, Neli Ulrich, Ryan M. O’Connell, William W. Tang, Zac Stephens, June L. Round   +6 more
openalex   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Chemotherapy driven alterations in NK cell receptors and ligands in high grade serous ovarian cancer. [PDF]

Front Immunol
Kumar P, Ranmale S, Mehta S, Tongaonkar H, Maniar V, Mania-Pramanik J.   +5 more
europepmc   +1 more source