Results 51 to 60 of about 262,765 (147)

NK-cell fratricide: Dynamic crosstalk between NK and cancer cells [PDF]

OncoImmunology, 2013
The intercellular transfer of plasma membrane patches, also known as trogocytosis, has a strong impact on the function and fate of immune cells. We have recently shown that natural killer (NK) cells undergo fratricide following the trogocytosis-mediated acquisition of tumor-derived NKG2D ligands.
Nakamura, Kyohei, Nakayama, Masafumi, Kawano, Mitsuko, Ishii, Tomonori, Harigae, Hideo, Ogasawara, Kouetsu   +5 more
openaire   +2 more sources

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

eLife, 2014
Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines.
Dorothy K Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A Pak-Wittel, Maxim N Artyomov, Yulia Ivanova, Chao Zhong, Julie M Chase, Paul B Rothman, Jenny Yu, Joan K Riley, Jinfang Zhu, Zhigang Tian, Wayne M Yokoyama   +13 more
doaj   +1 more source

Migration of NK cells

, 2006
NK cells were initially thought to be endowed with a particular migratory pattern and to mainly circulate in the blood. The recent findings reviewed here highlight that NK cells can exhibit different predilictions for tissue compartments, i.e., lymph nodes, inflamed tissues, etc., where they can play an important role as active participants in ...
GISMONDI, Angela, SANTONI, Angela
openaire   +2 more sources

MACC1 facilitates the escape of nasopharyngeal carcinoma cells from killing by natural killer cells

Biotechnology & Biotechnological Equipment, 2019
This study examined the regulation of phenotype and function of natural killer (NK) cells by nasopharyngeal carcinoma (NPC) cells with metastasis-associated in colon cancer-1 (MACC1) overexpression.
Chong Zhao, Yuehua Liu, Zhuoping Liang, Huajun Feng, Sheng’en Xu   +4 more
doaj   +1 more source

Targeted immune cell therapy for hepatocellular carcinoma using expanded liver mononuclear cell-derived natural killer cells

Neoplasia: An International Journal for Oncology Research
Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers but are frequently deficient or dysfunctional in patients with hepatocellular carcinoma (HCC).
Xin Hu, Yifang Shui, Seiichi Shimizu, Seisuke Sakamoto, Mureo Kasahara, Seiji Okada, Wen-Zhi Guo, Masayuki Fujino, Xiao-Kang Li   +8 more
doaj   +1 more source

Aggressive NK-Cell Leukemia [PDF]

Frontiers in Pediatrics, 2018
Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells closely associated with Epstein-Barr virus (EBV) and more common in East Asia than in other areas. Significant variations exist in the morphology of ANKL tumor cells, from typical large granular lymphocyte morphology to highly atypical features with ...
openaire   +3 more sources

Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential

mBio
The latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies to control the HIV reservoir is critical.
Yue Wang, Yidi Li, Jiaqi Chen, Chenxi Guo, Xiaowen Yu, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang   +11 more
doaj   +1 more source

Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

The Scientific World Journal, 2013
Objective. To investigate VIP effect on the cytotoxicity of NK cell to gastric cancer cells in vitro and the relation between the effect with the NKG2D signal molecules in NK cells. Material and Methods.
Chong Wang, Xi-Jin Zhou, Yuan-yuan Li, Juan Wan, Le-ying Yang, Guo-Hua Li   +5 more
doaj   +1 more source

Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma

Frontiers in Immunology
IntroductionNatural killer (NK) cells play a pivotal role in immune surveillance in the liver. We aimed to identify potential targets for NK cell-mediated immune intervention by revealing the functional molecules on NK cells in HCC patients.MethodsTo ...
Toshihiro Sakata, Toshihiro Sakata, Sachiyo Yoshio, Taiji Yamazoe, Taizo Mori, Eiji Kakazu, Yoshihiko Aoki, Nobuyoshi Aoyanagi, Toru Okamoto, Takanori Ito, Hidenori Toyoda, Takumi Kawaguchi, Yoshihiro Ono, Yu Takahashi, Akinobu Taketomi, Tatsuya Kanto   +15 more
doaj   +1 more source

Feeder cell training shapes the phenotype and function of in vitro expanded natural killer cells

MedComm
Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba   +8 more
doaj   +1 more source