Results 71 to 80 of about 582,983 (289)

Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Scientific Reports
Immunotherapy employing natural killer (NK) cells has emerged as a transformative approach to treating hematological malignancies. The reprogramming of NK cells by incorporating a chimeric antigen receptor (CAR) equipped with potent signaling domains has
Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells

Frontiers in Immunology, 2013
Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet, Mélanie eGillard-Bocquet, Mélanie eGillard-Bocquet, Charles eCaer, Charles eCaer, Charles eCaer, Nicolas eCagnard, Nicolas eCagnard, Lucile eCrozet, Lucile eCrozet, Lucile eCrozet, Mikael ePerez, Mikael ePerez, Mikael ePerez, Wolf Hervé eFridman, Wolf Hervé eFridman, Wolf Hervé eFridman, Catherine eSautes-fridman, Catherine eSautes-fridman, Catherine eSautes-fridman, Isabelle eCremer, Isabelle eCremer, Isabelle eCremer   +22 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cryopreserved PM21-Particle-Expanded Natural Killer Cells Maintain Cytotoxicity and Effector Functions In Vitro and In Vivo

Frontiers in Immunology, 2022
There is a great interest in developing natural killer (NK) cells as adoptive cancer immunotherapy. For off-the-shelf approaches and to conduct multicenter clinical trials, cryopreserved NK cells are the preferred product.
Jeremiah L. Oyer, Tayler J. Croom-Perez, Thomas A. Dieffenthaller, Liza D. Robles-Carillo, Sarah B. Gitto, Sarah B. Gitto, Deborah A. Altomare, Alicja J. Copik   +7 more
doaj   +1 more source

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]

, 2017
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R, Paolini, R., Quatrini, L, Santoni, A   +3 more
core   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Advances in Induced Pluripotent Stem Cell-Derived Natural Killer Cell Therapy

Cells
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of killing virus-infected cells and/or cancer cells. The commonly used NK cells for therapeutic applications include primary NK cells and immortalized NK cell lines ...
Wenhua Qiao, Peng Dong, Hui Chen, Jianmin Zhang   +3 more
doaj   +1 more source

Functions of liver natural killer cells are dependent on the severity of liver inflammation and fibrosis in chronic hepatitis C.

PLoS ONE, 2014
During chronic hepatitis C virus (HCV) infection, the role of intra-hepatic (IH) natural killer (NK) cells is still controversial. To clarify their functions, we investigated anti-viral and cytotoxic activity of NK cells in human fresh liver biopsies. We
Emilie Fugier, Hélène Marche, Marie-Ange Thélu, Zuzana Macek Jílková, Nicolas Van Campenhout, Tania Dufeu-Duchesne, Vincent Leroy, Jean-Pierre Zarski, Nathalie Sturm, Patrice N Marche, Evelyne Jouvin-Marche   +10 more
doaj   +1 more source

CD33 Delineates Two Functionally Distinct NK Cell Populations Divergent in Cytokine Production and Antibody-Mediated Cellular Cytotoxicity

Frontiers in Immunology, 2022
The generation and expansion of functionally competent NK cells in vitro is of great interest for their application in immunotherapy of cancer. Since CD33 constitutes a promising target for immunotherapy of myeloid malignancies, NK cells expressing a ...
Maryam Hejazi, Congcong Zhang, Sabrina B. Bennstein, Vera Balz, Sarah B. Reusing, Sarah B. Reusing, Melissa Quadflieg, Keven Hoerster, Stefan Heinrichs, Helmut Hanenberg, Sebastian Oberbeck, Marcus Nitsche, Sophie Cramer, Rita Pfeifer, Pranav Oberoi, Heiko Rühl, Johannes Oldenburg, Peter Brossart, Peter A. Horn, Florian Babor, Winfried S. Wels, Johannes C. Fischer, Nina Möker, Markus Uhrberg   +23 more
doaj   +1 more source