Results 131 to 140 of about 4,280 (166)

Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? [PDF]

Pathogens
Preston H, Casey R, Ferris E, Kerr-Jones L, Jones L, Latif F, Clement M, Aicheler RJ, Wang ECY, Stanton RJ, Fielding CA.   +10 more
europepmc   +1 more source

Peptide-specific natural killer cell receptors. [PDF]

Oxf Open Immunol
Sim MJW, Li B, Long EO.
europepmc   +1 more source

Advances in natural killer cell immunotherapy for hematologic malignancies. [PDF]

Cancer Biol Ther
Hu H, Xiong Y, Xia M, Sheng L.
europepmc   +1 more source

The Association of HLA-E Ligand and NKG2 Receptor Variation With Relapse and Mortality After Haploidentical Related Donor Transplantation. [PDF]

Transplant Cell Ther
Petersdorf EW, McKallor C, Malkki M, Hsu K, He M, Spellman SR, Gooley T, Stevenson P.   +7 more
europepmc   +1 more source

Phenotypes, mechanisms, and therapeutic strategies of natural killer cell immunosenescence. [PDF]

Immun Ageing
Guo Z, Wu F, Chen Y, Xu J, Chen Z.
europepmc   +1 more source

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells. [PDF]

Sci Rep
Hiura S, Kuwasaki Y, Nishikawa Y, Kimura T, Yoshida S, Nakayama M, Makino T, Ueno S.   +7 more
europepmc   +1 more source

Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia

Molecular Therapy, 2021
Natural killer (NK) cells mediate the cytolysis of transformed cells and are currently used as an adoptive cellular therapy to treat cancer. Infection with human cytomegalovirus has been shown to expand a subset of "adaptive" NK cells expressing the activation receptor NKG2C that have preferred functional attributes distinct from conventional NK cells.
Tom T Lee, Jeffrey S Miller, Hongbo Wang   +2 more
exaly   +3 more sources

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

Archivum Immunologiae Et Therapiae Experimentalis, 2023
AbstractThe interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells.
Katarzyna Bogunia-Kubik, Aleksandra Marzec-Przyszlak, JAGODA Siemaszko   +2 more
exaly   +4 more sources

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CD56dimCD57−NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+NKG2C+ memory-like NK cells

Journal of Leukocyte Biology, 2020
Abstract Formation of the adaptive-like NK cell subset in response to HCMV infection is associated with epigenetic rearrangements, accompanied by multiple changes in the protein expression. This includes a decrease in the expression level of the adapter chain FcεRIγ, NKp30, and NKG2A receptors and an increase in the expression of NKG2C ...
Polina A Kobyzeva, Maria A Streltsova, Sofya A Erokhina, Leonid M Kanevskiy, William G Telford, Alexander M Sapozhnikov, Elena I Kovalenko   +6 more
openaire   +2 more sources

Allogeneic NKG2C-positive NK cells for immunotherapy of glioblastoma multiforme

2021
Objective: NKG2C-positive natural killer (NK) cells represents a small NK cell subset, which is found in higher frequency in human cytomegalovirus (HCMV) seropositive patients. NKG2C+ NK cells can recognize target cells displaying HLA-E loaded with intracellularly processed ER signal peptides (sp)[for full text, please go to the a.m. URL]
Murad, S, Michen, S, Becker, A, Sagerer, A, Füssel, M, Schackert, G, Momburg, F, Temme, A   +7 more
openaire   +2 more sources