Results 191 to 200 of about 30,886 (233)
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Nature Immunology, 2010
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection ...
Dale Godfrey +2 more
exaly +4 more sources
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection ...
Dale Godfrey +2 more
exaly +4 more sources
Annual Review of Immunology, 2007
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic precursors through instructive signals emanating during TCR engagement by CD1d-expressing cortical thymocytes. Their semi-invariant αβ TCRs recognize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial α-glycuronylceramides found in the cell ...
Albert, Bendelac +2 more
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Recognized more than a decade ago, NKT cells differentiate from mainstream thymic precursors through instructive signals emanating during TCR engagement by CD1d-expressing cortical thymocytes. Their semi-invariant αβ TCRs recognize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial α-glycuronylceramides found in the cell ...
Albert, Bendelac +2 more
openaire +2 more sources
Role of NKT Cells in the Digestive System. II. NKT cells and diabetes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007Natural killer T (NKT) cells are a subset of regulatory T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related glycoprotein CD1d. NKT cells have been implicated in regulating the progression of Type 1 diabetes (T1D) in human patients and in an animal model for T1D.
Lan, Wu, Luc, Van Kaer
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Frontiers of Medicine, 2018
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases.
Shasha, Zhu, Huimin, Zhang, Li, Bai
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Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases.
Shasha, Zhu, Huimin, Zhang, Li, Bai
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Invariant NKT Cells and Tolerance
International Reviews of Immunology, 2007Invariant natural killer T (iNKT) cells are innate cells that can bias an immune response toward inflammation or toward a negative regulatory response. iNKT cells can produce cytokines immediately on exposure to activating signals, but the role of iNKT cells in the differentiation of T regulatory (Treg) cells and peripheral tolerance was elucidated ...
Michael, Nowak, Joan, Stein-Streilein
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Nature Immunology, 2009
It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D, Burrows +2 more
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It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D, Burrows +2 more
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Immunology & Cell Biology, 2004
Over the past 10 years a new population of cells has been the focus of much attention. The functions of these unique lymphocytes, characterized by the concomitant expression of T‐ and NK‐cell markers and thus termed NKT cells, have been implicated in many diverse aspects of immunity, including regulation of autoimmune disorders, control of tumour ...
Serani L H, Van Dommelen +1 more
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Over the past 10 years a new population of cells has been the focus of much attention. The functions of these unique lymphocytes, characterized by the concomitant expression of T‐ and NK‐cell markers and thus termed NKT cells, have been implicated in many diverse aspects of immunity, including regulation of autoimmune disorders, control of tumour ...
Serani L H, Van Dommelen +1 more
openaire +2 more sources
NKT Cells: The Culprits of Sepsis?
Journal of Surgical Research, 2011Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex pro-inflammatory cascades that include the activation of various immune cells and the exuberant secretion of pro-inflammatory cytokines by these cells. Natural killer T-cells (
Briana, Leung, Hobart W, Harris
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Development and selection of NKT cells
Current Opinion in Immunology, 2002NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their developmental origin.
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The unconventional lifestyle of NKT cells
Nature Reviews Immunology, 2002Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the invariant Vα14–Jα18 T-cell receptor (known here as Vα14i T cells) from conventional T cells. Because of their apparent self-reactivity, their expression of natural-killer receptors and their capacity to secrete large quantities of cytokines rapidly — including ...
Mitchell, Kronenberg, Laurent, Gapin
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