Results 191 to 200 of about 5,157 (213)
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T Cells and NKT Cells in the Pathogenesis of Asthma
Annual Review of Medicine, 2008Asthma is an immunological disease with multiple inflammatory and clinical phenotypes, characterized by symptoms of wheezing, shortness of breath, and coughing due to airway hyperreactivity (AHR) and reversible airway obstruction. In allergic asthma, the most common form of asthma, airway inflammation is mediated by adaptive immune recognition of ...
Everett H, Meyer +2 more
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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
Clinical Reviews in Allergy & ImmunologyNKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma. Activating iNKT induces increasing IFN-γ, TGF-β, IL-2, and IL-10 potentially suppressing allergic asthma.
Mohadeseh Mohammad, Taheri +3 more
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Roles of NKT cells in cancer immunotherapy
Archives of Pharmacal Research, 2019Cancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer. Among diverse immune populations, invariant natural killer T (iNKT) cells have shown potent antitumor activity by linking innate and adaptive immune systems. Upon activation by lipid antigens on CD1d molecules, iNKT cells rapidly produce various cytokines and trigger
Eun-Ah, Bae +4 more
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NKT cell subsets in infection and inflammation
Immunology Letters, 2003We recently identified two stably expressed cell surface markers, IL-18R and ST2L, which are selectively expressed on T1/NK1 and T2/NK2 cells, respectively. Here we use these molecules in direct ex vivo analysis of PBMCs from patients with AIDS, psoriasis (PS) atherosclerosis and to show the importance of these markers as determinants of the functional
Chan, WL +5 more
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NKT Cell Responses to Glycolipid Activation
2009NKT cells are a distinct lineage of T lymphocytes that are usually identified by the co-expression of the semi-invariant CD1d-restricted alphabeta TCR and the NK1.1 allelic marker of NK lineage receptors in the C57BL/6 mice and related strains. NKT cells can be subdivided based on CD4/CD8 expression and on tissue of origin.
Josianne Nitcheu, Tefit +2 more
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Liver invariant NKT cells and listeriosis
Microbes and Infection, 2008The invariant (i) NKT cells represent unique T lymphocytes expressing TCRValpha14. Although iNKT cells have been regarded as T lymphocytes expressing NK1.1, they do not consistently express this marker. NK1.1 allows recognition of "missing-self" and thus controls inhibition/activation of iNKT cells.
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The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead
Cancers, 2021Adam Nelson +2 more
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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Cell, 2018Patricia Barral +2 more
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