Results 211 to 220 of about 58,001 (251)

Acute eosinophilic pneumonia associated with elevated NKT cell response in COVID-19 patients

open access: yes, 2020
Kim D   +16 more
europepmc   +1 more source

Raising the NKT cell family

Nature Immunology, 2010
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection ...
Dale Godfrey, Alan G Baxter
exaly   +4 more sources

Control points in NKT-cell development

Nature Reviews Immunology, 2007
CD1d-dependent natural killer T (NKT) cells are a unique T-cell subset with the ability to regulate the immune system in response to a broad range of diseases. That low NKT-cell numbers are associated with many different disease states in mice and humans, combined with the fact that NKT-cell numbers vary widely between individuals, makes it crucial to ...
Dale Godfrey, Stuart Berzins
exaly   +3 more sources

Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral Blood

open access: yesFrontiers in Cell and Developmental Biology, 2020
Vα24-invariant human natural killer T (NKT) cells comprise a unique subset of CD1d-restricted T cells with potent immune regulatory function and are involved in the development of a variety of human diseases.
Li Zhou, Indra Adrianto, Xiaojun Wu
exaly   +3 more sources

NKT cells in liver diseases

Frontiers of Medicine, 2018
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases.
Shasha, Zhu, Huimin, Zhang, Li, Bai
openaire   +2 more sources

NKT Cell Networks in the Regulation of Tumor Immunity

open access: yesFrontiers in Immunology, 2014
CD1d-restricted natural killer T (NKT) cells lie at the interface between the innate and adaptive immune systems and are important mediators of immune responses and tumor immunosurveillance.
Jay A Berzofsky, Masaki Terabe
exaly   +3 more sources

NKT cells and viral immunity

Immunology & Cell Biology, 2004
Over the past 10 years a new population of cells has been the focus of much attention. The functions of these unique lymphocytes, characterized by the concomitant expression of T‐ and NK‐cell markers and thus termed NKT cells, have been implicated in many diverse aspects of immunity, including regulation of autoimmune disorders, control of tumour ...
Serani L H, Van Dommelen   +1 more
openaire   +2 more sources

Invariant NKT Cells and Tolerance

International Reviews of Immunology, 2007
Invariant natural killer T (iNKT) cells are innate cells that can bias an immune response toward inflammation or toward a negative regulatory response. iNKT cells can produce cytokines immediately on exposure to activating signals, but the role of iNKT cells in the differentiation of T regulatory (Treg) cells and peripheral tolerance was elucidated ...
Michael, Nowak, Joan, Stein-Streilein
openaire   +2 more sources

The Biology of NKT Cells

Annual Review of Immunology, 2007
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic precursors through instructive signals emanating during TCR engagement by CD1d-expressing cortical thymocytes. Their semi-invariant αβ TCRs recognize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial α-glycuronylceramides found in the cell ...
Albert, Bendelac   +2 more
openaire   +2 more sources

NKT cells in p53 deficiency

Blood, 2009
Abstract In this issue of Blood, Swann and colleagues show that type I NKT cells mediate protection against tumor development in p53-deficient mice.
Madhav V, Dhodapkar, Natalia, Neparidze
openaire   +2 more sources

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