Results 221 to 230 of about 58,001 (251)

Role of NKT Cells in the Digestive System. II. NKT cells and diabetes

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007
Natural killer T (NKT) cells are a subset of regulatory T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related glycoprotein CD1d. NKT cells have been implicated in regulating the progression of Type 1 diabetes (T1D) in human patients and in an animal model for T1D.
Lan, Wu, Luc, Van Kaer
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Retroviral Transduction of NKT Hybridoma Cells

2021
Natural killer T (NKT) cells have been shown to bridge innate and adaptive immunity. However, the rare population and hard-to-transfect of primary NKT cells slow down our understanding of cellular and molecular mechanisms of NKT development and function.
Ke, Wang, Rong, Jin, Qing, Ge
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NKT cells and HIV infection

Microbes and Infection, 2003
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens.
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NKT cells turn ten

Nature Immunology, 2009
It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D Burrows, Mitchell Kronenberg, Masaru Taniguchi   +2 more
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Genetic control of NKT cell numbers

Immunology & Cell Biology, 2004
NKT cells play a critical role in shaping the character and strength of a wide range of immune responses, including those against pathogens, tumours, allografts and autologous tissues. Because numbers of NKT cells affect clinical outcomes in a wide range of disease models, and this characteristic demonstrates allelic variation, the mapping of the ...
Jordan, Margaret A., Fletcher, Julie, Baxter, Alan G.   +2 more
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ICOS costimulates invariant NKT cell activation

Biochemical and Biophysical Research Communications, 2005
It has been reported that costimulatory molecules, CD80/86-CD28 and CD154-CD40, critically contribute to activation of CD1d-restricted invariant NKT (iNKT) cells. Here we have demonstrated that ICOS, a new member of the CD28 family, plays a substantial role in iNKT cell activation. iNKT cells constitutively expressed ICOS as well as CD28 independently,
Hiroshi, Kaneda, Kazuyoshi, Takeda, Tsuyoshi, Ota, Yuki, Kaduka, Hisaya, Akiba, Yoshinori, Ikarashi, Hiro, Wakasugi, Mitchell, Kronenberg, Katsuyuki, Kinoshita, Hideo, Yagita, Ko, Okumura   +10 more
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NKT cells — conductors of tumor immunity?

Current Opinion in Immunology, 2002
NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other ...
Mark J, Smyth, Nadine Y, Crowe, Yoshihiro, Hayakawa, Kazuyoshi, Takeda, Hideo, Yagita, Dale I, Godfrey   +5 more
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Glycosphingolipids Activated NKT Cells

Science's STKE, 2005
A subset of natural killer T (NKT) cells with a specialized form of the T cell receptor (TCR) containing an invariant TCR α chain (in mice Vα14i, in humans Vα24i) that recognizes antigens presented by the major histocompatibility complex (MHC)-like molecule CD1d is involved in the immune response to microbial pathogens.
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Liver invariant NKT cells and listeriosis

Microbes and Infection, 2008
The invariant (i) NKT cells represent unique T lymphocytes expressing TCRValpha14. Although iNKT cells have been regarded as T lymphocytes expressing NK1.1, they do not consistently express this marker. NK1.1 allows recognition of "missing-self" and thus controls inhibition/activation of iNKT cells.
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NKT Cell Responses to Glycolipid Activation

2009
NKT cells are a distinct lineage of T lymphocytes that are usually identified by the co-expression of the semi-invariant CD1d-restricted alphabeta TCR and the NK1.1 allelic marker of NK lineage receptors in the C57BL/6 mice and related strains. NKT cells can be subdivided based on CD4/CD8 expression and on tissue of origin.
Josianne Nitcheu, Tefit, Gwyn, Davies, Vincent, Serra   +2 more
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