Results 221 to 230 of about 58,157 (254)
Some of the next articles are maybe not open access.
Regulatory T cells induce CD4− NKT cell anergy and suppress NKT cell cytotoxic function
Cancer Immunology, Immunotherapy, 2019Due to the strong tumoricidal activities of activated natural killer T (NKT) cells, invariant NKT cell-based immunotherapy has shown promising clinical efficacy. However, suppressive factors, such as regulatory T cells (Tregs), may be obstacles in the use of NKT cell-based cancer immunotherapy for advanced cancer patients.
Fumie, Ihara +9 more
openaire +2 more sources
Blood, 2009
Abstract In this issue of Blood, Swann and colleagues show that type I NKT cells mediate protection against tumor development in p53-deficient mice.
Madhav V, Dhodapkar, Natalia, Neparidze
openaire +2 more sources
Abstract In this issue of Blood, Swann and colleagues show that type I NKT cells mediate protection against tumor development in p53-deficient mice.
Madhav V, Dhodapkar, Natalia, Neparidze
openaire +2 more sources
Role of NKT Cells in the Digestive System. II. NKT cells and diabetes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007Natural killer T (NKT) cells are a subset of regulatory T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related glycoprotein CD1d. NKT cells have been implicated in regulating the progression of Type 1 diabetes (T1D) in human patients and in an animal model for T1D.
Lan, Wu, Luc, Van Kaer
openaire +2 more sources
Retroviral Transduction of NKT Hybridoma Cells
2021Natural killer T (NKT) cells have been shown to bridge innate and adaptive immunity. However, the rare population and hard-to-transfect of primary NKT cells slow down our understanding of cellular and molecular mechanisms of NKT development and function.
Ke, Wang, Rong, Jin, Qing, Ge
openaire +2 more sources
Microbes and Infection, 2003
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens.
openaire +2 more sources
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens.
openaire +2 more sources
Nature Immunology, 2009
It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D Burrows +2 more
openaire +1 more source
It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D Burrows +2 more
openaire +1 more source
Genetic control of NKT cell numbers
Immunology & Cell Biology, 2004NKT cells play a critical role in shaping the character and strength of a wide range of immune responses, including those against pathogens, tumours, allografts and autologous tissues. Because numbers of NKT cells affect clinical outcomes in a wide range of disease models, and this characteristic demonstrates allelic variation, the mapping of the ...
Jordan, Margaret A. +2 more
openaire +3 more sources
ICOS costimulates invariant NKT cell activation
Biochemical and Biophysical Research Communications, 2005It has been reported that costimulatory molecules, CD80/86-CD28 and CD154-CD40, critically contribute to activation of CD1d-restricted invariant NKT (iNKT) cells. Here we have demonstrated that ICOS, a new member of the CD28 family, plays a substantial role in iNKT cell activation. iNKT cells constitutively expressed ICOS as well as CD28 independently,
Hiroshi, Kaneda +10 more
openaire +2 more sources
NKT cells — conductors of tumor immunity?
Current Opinion in Immunology, 2002NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other ...
Mark J, Smyth +5 more
openaire +2 more sources
Glycosphingolipids Activated NKT Cells
Science's STKE, 2005A subset of natural killer T (NKT) cells with a specialized form of the T cell receptor (TCR) containing an invariant TCR α chain (in mice Vα14i, in humans Vα24i) that recognizes antigens presented by the major histocompatibility complex (MHC)-like molecule CD1d is involved in the immune response to microbial pathogens.
openaire +1 more source