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A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells. [PDF]
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Annual Review of Immunology, 2007
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic precursors through instructive signals emanating during TCR engagement by CD1d-expressing cortical thymocytes. Their semi-invariant αβ TCRs recognize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial α-glycuronylceramides found in the cell ...
Albert, Bendelac +2 more
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Recognized more than a decade ago, NKT cells differentiate from mainstream thymic precursors through instructive signals emanating during TCR engagement by CD1d-expressing cortical thymocytes. Their semi-invariant αβ TCRs recognize isoglobotrihexosylceramide, a mammalian glycosphingolipid, as well as microbial α-glycuronylceramides found in the cell ...
Albert, Bendelac +2 more
openaire +2 more sources
Role of NKT Cells in the Digestive System. II. NKT cells and diabetes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007Natural killer T (NKT) cells are a subset of regulatory T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related glycoprotein CD1d. NKT cells have been implicated in regulating the progression of Type 1 diabetes (T1D) in human patients and in an animal model for T1D.
Lan, Wu, Luc, Van Kaer
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Frontiers of Medicine, 2018
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases.
Shasha, Zhu, Huimin, Zhang, Li, Bai
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Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases.
Shasha, Zhu, Huimin, Zhang, Li, Bai
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Nature Immunology, 2010
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection ...
Godfrey, Dale I. +2 more
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Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection ...
Godfrey, Dale I. +2 more
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Invariant NKT Cells and Tolerance
International Reviews of Immunology, 2007Invariant natural killer T (iNKT) cells are innate cells that can bias an immune response toward inflammation or toward a negative regulatory response. iNKT cells can produce cytokines immediately on exposure to activating signals, but the role of iNKT cells in the differentiation of T regulatory (Treg) cells and peripheral tolerance was elucidated ...
Michael, Nowak, Joan, Stein-Streilein
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Nature Immunology, 2009
It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D, Burrows +2 more
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It has been 10 years since the first workshop on natural killer T cells helped to launch a growth phase for this field of research.
Peter D, Burrows +2 more
openaire +2 more sources