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Immunology & Cell Biology, 2004
Over the past 10 years a new population of cells has been the focus of much attention. The functions of these unique lymphocytes, characterized by the concomitant expression of T‐ and NK‐cell markers and thus termed NKT cells, have been implicated in many diverse aspects of immunity, including regulation of autoimmune disorders, control of tumour ...
Serani L H, Van Dommelen +1 more
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Over the past 10 years a new population of cells has been the focus of much attention. The functions of these unique lymphocytes, characterized by the concomitant expression of T‐ and NK‐cell markers and thus termed NKT cells, have been implicated in many diverse aspects of immunity, including regulation of autoimmune disorders, control of tumour ...
Serani L H, Van Dommelen +1 more
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NKT Cells: The Culprits of Sepsis?
Journal of Surgical Research, 2011Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex pro-inflammatory cascades that include the activation of various immune cells and the exuberant secretion of pro-inflammatory cytokines by these cells. Natural killer T-cells (
Briana, Leung, Hobart W, Harris
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The unconventional lifestyle of NKT cells
Nature Reviews Immunology, 2002Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the invariant Vα14–Jα18 T-cell receptor (known here as Vα14i T cells) from conventional T cells. Because of their apparent self-reactivity, their expression of natural-killer receptors and their capacity to secrete large quantities of cytokines rapidly — including ...
Mitchell, Kronenberg, Laurent, Gapin
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Development and selection of NKT cells
Current Opinion in Immunology, 2002NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their developmental origin.
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Blood, 2009
Abstract In this issue of Blood, Swann and colleagues show that type I NKT cells mediate protection against tumor development in p53-deficient mice.
Madhav V, Dhodapkar, Natalia, Neparidze
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Abstract In this issue of Blood, Swann and colleagues show that type I NKT cells mediate protection against tumor development in p53-deficient mice.
Madhav V, Dhodapkar, Natalia, Neparidze
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Microbes and Infection, 2003
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens.
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Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CD1d. NKT cells regulate a wide variety of immune functions against autoantigens and pathogens.
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Retroviral Transduction of NKT Hybridoma Cells
2021Natural killer T (NKT) cells have been shown to bridge innate and adaptive immunity. However, the rare population and hard-to-transfect of primary NKT cells slow down our understanding of cellular and molecular mechanisms of NKT development and function.
Ke, Wang, Rong, Jin, Qing, Ge
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Role of NKT Cells in the Digestive System. III. Role of NKT cells in intestinal immunity
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007Natural killer T (NKT) cells are a small subset of unconventional T cells that recognize lipid antigens presented by the nonclassical major histocompatibility complex (MHC) class I molecule CD1d. NKT cells are involved in the host response to a variety of microbial pathogens and likely commensals. In the intestine, invariant and noninvariant NKT cells
Zeissig, S +4 more
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T Cells and NKT Cells in the Pathogenesis of Asthma
Annual Review of Medicine, 2008Asthma is an immunological disease with multiple inflammatory and clinical phenotypes, characterized by symptoms of wheezing, shortness of breath, and coughing due to airway hyperreactivity (AHR) and reversible airway obstruction. In allergic asthma, the most common form of asthma, airway inflammation is mediated by adaptive immune recognition of ...
Everett H, Meyer +2 more
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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
Clinical Reviews in Allergy & ImmunologyNKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma. Activating iNKT induces increasing IFN-γ, TGF-β, IL-2, and IL-10 potentially suppressing allergic asthma.
Mohadeseh Mohammad, Taheri +3 more
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