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Liver invariant NKT cells and listeriosis
Microbes and Infection, 2008The invariant (i) NKT cells represent unique T lymphocytes expressing TCRValpha14. Although iNKT cells have been regarded as T lymphocytes expressing NK1.1, they do not consistently express this marker. NK1.1 allows recognition of "missing-self" and thus controls inhibition/activation of iNKT cells.
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NKT Cell Responses to Glycolipid Activation
2009NKT cells are a distinct lineage of T lymphocytes that are usually identified by the co-expression of the semi-invariant CD1d-restricted alphabeta TCR and the NK1.1 allelic marker of NK lineage receptors in the C57BL/6 mice and related strains. NKT cells can be subdivided based on CD4/CD8 expression and on tissue of origin.
Josianne Nitcheu, Tefit +2 more
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Development and selection of NKT cells
Current Opinion in Immunology, 2002NKT cells utilize a restricted alphabeta TCR repertoire that recognizes glycolipids in association with CD1d. The recent development of fluorescent CD1d tetramers loaded with the synthetic glycolipid alpha-galactosyl-ceramide has led to a clearer definition of NKT-cell subsets as well as important insights into their developmental origin.
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2016
CD1d-restricted invariant natural killer T (NKT) cells are a specialized innate lymphocyte subset that recognizes a glycolipid antigen via the invariant T-cell receptor. Ligand-activated NKT cells display direct antitumor activities against various tumors.
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CD1d-restricted invariant natural killer T (NKT) cells are a specialized innate lymphocyte subset that recognizes a glycolipid antigen via the invariant T-cell receptor. Ligand-activated NKT cells display direct antitumor activities against various tumors.
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Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Nature Reviews Immunology, 2020Daniel G Pellicci +2 more
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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Cell, 2018Mauro Gaya +2 more
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The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response
Annual Review of Immunology, 2003Masaru Taniguchi +2 more
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Targeting natural killer cells and natural killer T cells in cancer
Nature Reviews Immunology, 2012Eric Vivier +2 more
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Recognition of CD1d-restricted antigens by natural killer T cells
Nature Reviews Immunology, 2012Jamie Rossjohn +2 more
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