Results 121 to 130 of about 81,787 (272)

The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High‐Intensity Interval Training of Individuals With Obesity

Immunology, EarlyView.
This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Marina Tiemi Shio, Paula Rezende‐Teixeira, Carolina Nunes França   +8 more
wiley   +1 more source

The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis. [PDF]

Am J Pathol, 2022
Colunga Biancatelli RML, Solopov PA, Catravas JD.   +2 more
europepmc   +1 more source

Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two‐sample Mendelian randomization

Journal of Diabetes Investigation, EarlyView.
A schematic representation of the two‐sample Mendelian randomization framework used to investigate the causal association between circulating leukocyte traits and diabetic retinopathy. ABSTRACT Aims/Introduction Leukocytes are implicated in the inflammatory cascades of diabetic retinopathy (DR), but their causal roles remain ambiguous.
Yan Wang, Yunxian Gao, Zhiqiang Wang, Luhua Wu, Lixia Guo, Xiaoqiang Zhang, Jiaxin Wu, Shanshan Shang   +7 more
wiley   +1 more source

FERM domain containing kindlin 1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLR family pyrin domain containing 3/nuclear factor kappa B pathway. [PDF]

Exp Anim, 2023
Wei J, Yin J, Cui Y, Wang K, Hong M, Cui J.   +5 more
europepmc   +1 more source

Rice blast pathogen effector AvrPib compromises disease resistance by targeting Raf‐like protein kinase OsMAPKKK72 to inhibit MAPK signaling

Journal of Integrative Plant Biology, EarlyView.
The rice Raf‐like protein kinase OsMAPKKK72 acts as a scaffold to modulate MAPK signaling. To invade rice plants, the blast fungus delivers the effector AvrPib to target OsMAPKKK72, suppressing MAPK activation and rice blast resistance. ABSTRACT Phytopathogens, such as the rice blast fungus Magnaporthe oryzae, suppress plant immunity for reproduction ...
Zhanchun Wang, Guitao Zhong, Beibei Zhang, Yilin Xie, Yufan Gan, Dingzhong Tang, Wei Wang   +6 more
wiley   +1 more source

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

Nature Communications
NLR family proteins act as intracellular receptors. Gene duplication amplifies the number of NLR genes, and subsequent mutations occasionally provide modifications to the second gene that benefits immunity.
Yuying Li, Qiong Wang, Huimin Jia, Kazuya Ishikawa, Ken-ichi Kosami, Takahiro Ueba, Atsumi Tsujimoto, Miki Yamanaka, Yasuyuki Yabumoto, Daisuke Miki, Eriko Sasaki, Yoichiro Fukao, Masayuki Fujiwara, Takako Kaneko-Kawano, Li Tan, Chojiro Kojima, Rod A. Wing, Alfino Sebastian, Hideki Nishimura, Fumi Fukada, Qingfeng Niu, Motoki Shimizu, Kentaro Yoshida, Ryohei Terauchi, Ko Shimamoto, Yoji Kawano   +25 more
doaj   +1 more source

Gaining extensive resistance against clubroot disease through the disruption of a susceptibility gene

Journal of Integrative Plant Biology, EarlyView.
This Commentary examines research by Wu et al. showing that β‐1,3‐glucan synthase‐like 5 (GSL5) functions as a key gene for susceptibility to clubroot in Brassica family members by suppressing immunity regulated by jasmonic acid. Inaction of GSL5 through genome editing provides broad‐spectrum resistance to clubroot.
Qibin Wu, Zhen Zeng, Daowen Wang, Zheng Qing Fu, Youxiong Que   +4 more
wiley   +1 more source

Long noncoding RNA X-inactive specific transcript regulates NLR family pyrin domain containing 3/caspase-1-mediated pyroptosis in diabetic nephropathy. [PDF]

World J Diabetes, 2022
Xu J, Wang Q, Song YF, Xu XH, Zhu H, Chen PD, Ren YP.   +6 more
europepmc   +1 more source

NLR family pyrin domain containing 3 (NLRP3; NALP3); purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7) [PDF]

, 2011

openalex   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source