Results 221 to 230 of about 81,787 (272)
Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants [PDF]
Soohyun Oh +5 more
openalex +1 more source
β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver
Aging Cell, Volume 25, Issue 1, January 2026.β‐hydroxybutyrate (β‐HB) acts as an exercise mimetic to protect the aging liver. In aged models, exercise‐induced β‐HB delays liver aging by reversing macrophage senescence, blocking mtDNA/cGAS‐STING‐driven inflammation, and alleviating hepatocyte lipid deposition/PANoptosis.
Ke Li +7 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
Clinical Otolaryngology, Volume 51, Issue 1, Page 48-57, January 2026.ABSTRACT Objective To evaluate the prognostic significance of preoperative inflammatory markers including platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐lymphocyte ratio (NLR) and albumin‐to‐globulin ratio (AGR) in patients with laryngeal squamous cell carcinoma (LSCC) undergoing total laryngectomy (TL).
Noa Talmor +6 more
wiley +1 more source
The Overexpression of Sirtuin1 (SIRT1) Alleviated Lipopolysaccharide (LPS)-Induced Acute Kidney Injury (AKI) via Inhibiting the Activation of Nucleotide-Binding Oligomerization Domain-Like Receptors (NLR) Family Pyrin Domain Containing 3 (NLRP3) Inflammasome. [PDF]
Med Sci Monit, 2019 Gao Q, Zhu H.
europepmc +1 more source
Negative Frequency‐Dependent Selection Promotes Strain Structure in a Plant Pathogen
Ecology Letters, Volume 29, Issue 1, January 2026.Strains of the plant pathogen Pseudomonas syringae, defined by the combination of virulence factors known as effectors, exhibit in isolates from the Midwestern US a modular population structure congruent with core genome phylogeny. A stochastic and individual‐based computational model supports a role of negative frequency‐dependent selection in ...
Shuanger Li +5 more
wiley +1 more source
Proteome‐Guided Drug Target Discovery for Periodontitis
Journal of Clinical Periodontology, Volume 53, Issue 1, Page 127-136, January 2026.ABSTRACT Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods We integrated proteomics data from deCODE genetics with periodontitis genome‐wide association studies ...
Zoheir Alayash +8 more
wiley +1 more source
Role of the NLR gene family members in neuroinflammation and demyelination in the CNS
, 2019 Sushmita Jha
openalex +2 more sources
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Given the absence of curative treatments for neurodegenerative diseases, early detection and therapeutic intervention are critical to slowing disease progression. The last decade has seen accumulating evidence for microRNA dysregulation in circulating extracellular vesicles (EVs); however, assessing reproducibility between studies remains challenging ...
Aliyah Zaman +2 more
wiley +1 more source