Results 231 to 240 of about 81,787 (272)

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy

, 2018
Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Ya‐Hui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen   +14 more
openalex   +2 more sources

The Ralstonia solanacearum E3 Ligase Effector RipV1 Targets Plant U‐Box Domain‐Containing Receptor‐Like Cytoplasmic Kinases That Negatively Regulate Immunity in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
The Ralstonia solanacearum Novel E3 Ligase effector RipV1 ubiquitinates and enhances the accumulation of the plant U‐box‐containing receptor‐like cytoplasmic protein RLCK‐IXb‐1 that negatively regulates immune signalling. ABSTRACT Plants detect microbe‐associated molecular patterns from pathogens via plasma membrane‐localised receptors, which activate ...
Jihyun Choi, Thakshila Dharmasena, Yoonyoung Lee, Jacqueline Monaghan, Cécile Segonzac   +4 more
wiley   +1 more source

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. [PDF]

Hepatology, 2019
Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE.   +9 more
europepmc   +1 more source

The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
The effector RipAW facilitates R. solanacearum infection by suppressing CBP60g/SARD1‐dependent SA pathway and triggering CBP60g/SARD1‐independent root architecture changes. ABSTRACT CaM‐binding Protein 60‐like G (CBP60g) and Systemic Acquired Resistance Deficient 1 (SARD1) are key immune signalling regulators that redundantly promote salicylic acid (SA)
Huijuan Wang, Shouyang Fu, Tao Cao, Yang Niu, Shengyang Cheng, Qichang Gong, Hui Ma, Xiang Wang, Jinxue Hu, Min Chen, Dongdong Wang, Yong Zhang, Nuria S. Coll, Marc Valls, Qin Chen, Cuizhu Zhao, Yue Chen, Haibin Lu   +17 more
wiley   +1 more source

The Arabidopsis deNADding Enzyme DXO1 Modulates the Plant Immunity Response

Plant, Cell &Environment, Volume 49, Issue 1, Page 32-50, January 2026.
ABSTRACT DXO1, the only DXO homolog in Arabidopsis, due to its plant‐specific features, exhibits strong deNADding enzymatic activity but has no apparent role in 5′ QC. Despite its important contribution to plant RNA metabolism, the direct impact of DXO1 enzymatic activity on cellular processes appears surprisingly limited.
Anna Golisz‐Mocydlarz, Monika Zakrzewska‐Placzek, Michal Krzyszton, Nataliia Diachenko, Justyna Piotrowska, Wiktoria Kalbarczyk, Agnieszka Marasek‐Ciolakowska, Joanna Kufel   +7 more
wiley   +1 more source

The multifaceted roles of ketones in physiology

Experimental Physiology, Volume 111, Issue 1, Page 1-13, 1 January 2026.
Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Magnus J. Stenlund, John R. Ussher   +3 more
wiley   +1 more source

Systemic Inflammatory Response Index Has a Value for the Early Diagnosis and Short‐Term Prognostic Assessment of Severe Pneumonia in the Elderly

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
This article probed the value of systemic inflammatory response index (SIRI) in the early diagnosis and short‐term prognostic assessment of severe pneumonia (SPM) in the elderly. First, 266 elderly patients with pneumonia were retrospectively included and allocated into SPM and N‐SPM groups as per APACHE‐II scores.
Xiao Xu, Huajuan Xu, Ming Li, Shuying Yan, Huilin Chen, Alexandru Corlateanu   +5 more
wiley   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Neutrophil/Lymphocyte ratio an accurate and simple tool to identify severe acute pancreatitis and predict mortality risk. [PDF]

J Family Med Prim Care
Kumar S, Ekka NMP, Sinha DK, Kumar B, Kujur ADS, Mayank S, Darad S, Sahoo S, Singh A.   +8 more
europepmc   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source