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Miltirone promotes pyroptosis via increasing pyroptosis-related protein NLRP3 and AIM2 in kidney renal clear cell carcinoma. [PDF]

Front Immunol
Huang T, Wang Q, Gao Y, Wang H, Guo C, Song L, He P, Cai J.   +7 more
europepmc   +1 more source

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NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators.

European Journal of Pharmacology, 2023
Neuropathic pain is caused by the lesion or disease of the somatosensory system and can be initiated and/or maintained by both central and peripheral mechanisms.
P. Basu, C. Maier, D. Averitt, A. Basu
semanticscholar   +1 more source

Evolutionary history of the NLR gene families across lophotrochozoans

Gene, 2022
NOD-like receptor (NLR) genes are critical innate immune receptors in animals and plants. Lophotrochozoans represent one of the most species-rich superphyla that includes molluscs, segmented worms, flatworms, bryozoans, and other invertebrates, which is crucial to our understanding of immune system evolution in bilaterians.
Xiaofei Zhu, Kang Mu, Yi Wan, Linlin Zhang   +3 more
openaire   +2 more sources

Role of NLR Family Pyrin Domain-Containing 3 Inflammasome in the Activation of Pancreatic Stellate Cells.

Experimental Cell Research, 2021
NLRP3 inflammasome activation plays an important role in the development of pancreatic fibrosis. However, it is unclear whether the activation of the NLRP3 inflammasome is directly involved in the activation of Pancreatic stellate cells (PSCs).
Caixia Li, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, N. Cui, Shukun Zhang   +6 more
semanticscholar   +1 more source

Inflammasome-Independent Roles of NLR and ALR Family Members

2023
Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory ...
Suman, Gupta, Suzanne L, Cassel, Fayyaz S, Sutterwala   +2 more
openaire   +2 more sources

Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3.

Journal of Molecular and Cellular Cardiology, 2019
AIMS Doxorubicin (DOX), a widely used powerful chemotherapeutic component for cancer treatment, can give rise to severe cardiotoxicity that limits its clinical use.
L. Meng, Hui-Kuan Lin, Jie Zhang, N. Lin, Zhenzhu Sun, F. Gao, Hangqi Luo, T. Ni, Wenqiang Luo, J. Chi, Hangyuan Guo   +10 more
semanticscholar   +1 more source

Genome-wide identification, phylogenetic relationships and expression patterns of the NOD-like receptor (NLR) gene family in flounder (Paralichthys olivaceus).

Fish and Shellfish Immunology, 2023
NOD-like receptors (NLRs) are one of the pattern recognition receptors which have been widely known for identifying pathogens and regulating innate immunity in mammals, but the functions of the NLR gene family in teleost fish remain poorly understood. In
Yingqin Liu, X. Sheng, Xiaoqian Tang, J. Xing, Heng Chi, W. Zhan   +5 more
semanticscholar   +1 more source

Progresses on three pattern recognition receptor families (TLRs, RLRs and NLRs) in teleost

Developmental & Comparative Immunology, 2021
Pattern recognition receptors (PRRs) are a class of immune sensors that play crucial roles in detecting and responding to the conserved patterns of microorganisms. To date, many PRRs, such as TLRs, RLRs and NLRs, as well as their downstream molecules have been identified and characterized in teleost, while their ligands and immunoregulatory mechanisms ...
Zhiwei Liao, Jianguo Su
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Author Correction: The NLR gene family: from discovery to present day

Nature Reviews Immunology, 2023
Author Correction: The NLR gene family: from discovery to present ...
Linhoff, Michael W., Ting, Jenny P.-Y., Chou, Wei-Chun, Jha, Sushmita   +3 more
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MicroRNA‐4328 promotes lens epithelial cell apoptosis by targeting NLR family, apoptosis inhibitory protein in age‐related cataract

Cell Biochemistry and Function, 2019
Cataract is the leading cause of blindness in the world while the molecular mechanisms of cataracts pathogenesis are not well elucidated. Dysregulated microRNA (miRNA) expressions have been implicated in cataract. However, the precise role of miR‐4328 in
Jianfeng Zhu, L. Gong, Bojun Zhao
semanticscholar   +1 more source