Results 51 to 60 of about 81,787 (272)
New insights into the structure domain and function of NLR family CARD domain containing 5. [PDF]
Cell Commun SignalNOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization domain (NOD or NACHT), and a leucine-rich repeat (LRR) domain ...
Zhu H +8 more
europepmc +4 more sources
The Brassicaceae Family Displays Divergent, Shoot-Skewed NLR Resistance Gene Expression [PDF]
Plant Physiology, 2017 Nucleotide-binding site leucine-rich repeat resistance genes (NLRs) allow plants to detect microbial effectors. We hypothesized that NLR expression patterns could reflect organ-specific differences in effector challenge and tested this by carrying out a meta-analysis of expression data for 1,235 NLRs from nine plant species.
David Munch +6 more
openaire +4 more sources
Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes
Vaccines, 2022 Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are involved in modulating the innate immune responses of the trophoblast and the placenta in normal pregnancy.
Leying Zhang +5 more
doaj +1 more source
Frontiers in Plant Science, 2022 The largest family of disease resistance genes in plants are nucleotide-binding site leucine-rich repeat genes (NLRs). The products of these genes are responsible for recognizing avirulence proteins (Avr) of phytopathogens and triggering specific defense
Mariana de Lima Santos +5 more
doaj +1 more source
Frontiers in Plant Science, 2016 Plants have evolved an elaborate innate immune system against invading pathogens. Within this system, intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors are known play critical roles in effector-triggered immunity (ETI) plant ...
Eunyoung Seo +3 more
doaj +1 more source
Breaking plant family barriers: Sensor–helper NLR pairs enable cross‐kingdom immune defense [PDF]
Journal of Integrative Plant BiologyManman Zhang, Cheng Li, Fengquan Liu
openalex +2 more sources
Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member [PDF]
Journal of Biotechnology, 2012 NOD1 (NLRC1) is a member of the NLR family of innate immunity proteins, which are important cellular sensors of various pathogens. Deregulated NOD1 signaling is involved in various autoimmune, inflammatory, and allergic diseases, making it a potential target for drug discovery.
Nadav, Askari +3 more
openaire +2 more sources
CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses [PDF]
Proceedings of the American Thoracic Society, 2007 One of the most important advances in human immunology in the last decade has been the characterization of evolutionarily conserved molecular mediators important in controlling innate immunity. A prime example of this is the discovery of the mammalian Toll-like receptor family.
John D, Lich, Jenny P-Y, Ting
openaire +2 more sources
Dissection of Two Complex Clusters of Resistance Genes in Lettuce (Lactuca sativa)
Molecular Plant-Microbe Interactions, 2015 Of the over 50 phenotypic resistance genes mapped in lettuce, 25 colocalize to three major resistance clusters (MRC) on chromosomes 1, 2, and 4. Similarly, the majority of candidate resistance genes encoding nucleotide binding-leucine rich repeat (NLR ...
Marilena Christopoulou +5 more
doaj +1 more source
Early Pregnancy Modulates Expression of the Nod-like Receptor Family in Lymph Nodes of Ewes
Animals, 2022 NOD receptors (NLRs) mediate adaptive immune responses and immune tolerance. Nevertheless, it is not clear if gestation modulates the NLR signaling pathway in lymph nodes of ewes. In this study, lymph nodes of ewes were collected at day 16 of the estrous
Zhenyang Zhao +5 more
doaj +1 more source