Results 241 to 250 of about 113,850 (298)

Knockdown of SHP-2 delays renal tubular epithelial cell injury in diabetic nephropathy by inhibiting NLRP3 inflammasome-mediated pyroptosis

Open Life Sciences
Tian Panli, Ma Yanli, Shang Tao
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

A novel redox signalling axis mediates nicotine-induced podocyte injury. [PDF]

Front Pharmacol
Rahman MA, Yellu R, Pavirala V, Datta S, Koka S, Boini KM.   +5 more
europepmc   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Unveiling <i>Fusobacterium nucleatum</i>'s role in colorectal cancer: the inflammatory microenvironment connection. [PDF]

Front Immunol
Chen Y, Lu X, Liu K, Wen X, Du X, Zhang Y, Kang Y, Wang P, Zhang YJ.   +8 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

LncRNA HOTAIR/miR-9-5p/FOXP1 axis modulates cerebral ischemia-reperfusion injury via NLRP3 inflammasome activation. [PDF]

IBRO Neurosci Rep
Liu T, Zhu X, Zhuo F, Peng S.
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The Polyphenol-Enriched <i>Salix songarica</i> Extract Alleviate High-Fat, High-Cholesterol Diet-Induced Inflammation via the LPC18:1/GPR120/β-Arrestin-2/NLRP3 Signaling Pathway. [PDF]

Foods
Li H, Ma N, Dai X, Lin R, Yao Z, Yan X, Xu S, Hu Y, Zhang W, Wang H, Yang Q, Guo X, Zhang L.   +12 more
europepmc   +1 more source

Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis. [PDF]

Am J Respir Cell Mol Biol
Vaso M, Dukic M, Pennitz P, Manukyan A, Collum S, Lin W, Winder CL, Dunn WB, Schupp JC, Braubach P, Wygrecka M, Ren D, Suarez EE, Huang HJ, Hussain R, Patel B, Karmouty-Quintana H, Akalin A, Landthaler M, Nouailles G, Ochs M, Lopez-Rodriguez E, Giambelluca S.   +22 more
europepmc   +1 more source