Results 251 to 260 of about 131,202 (338)

Rebamipide (Mucosta®), a clinically approved drug, alleviates neuroinflammation and dopaminergic neurodegeneration in a Parkinson's disease model. [PDF]

J Neuroinflammation
Lim HS, Park J, Kim E, Lee W, Yun HY, Lee SH, Park G.   +6 more
europepmc   +1 more source

Turning on and off NLRP3 [PDF]

Nature Reviews Immunology, 2012
openaire   +3 more sources

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

Obesity, EarlyView.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Nicholas Clarke, Alan P. Watt   +6 more
wiley   +1 more source

In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome [PDF]

, 2012
Kazuo Kubota, Hidenori Ohnishi, Takahide Teramoto, Eiko Matsui, Kana Murase, Hiroyuki Kanoh, Zenichiro Kato, Hideo Kaneko, Mariko Seishima, Naomi Kondo   +9 more
openalex   +1 more source

Inflammasome-Mediated Neuroinflammation: A Key Driver in Alzheimer's Disease Pathogenesis. [PDF]

Biomolecules
McGroarty J, Salinas S, Evans H, Jimenez B, Tran V, Kadavakollu S, Vashist A, Atluri V.   +7 more
europepmc   +1 more source

Altered Bacteria Abundance Is Associated With Outcomes in Head and Neck Squamous Cell Carcinoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To determine if microbiome differences exist in head and neck squamous cell carcinoma (HNSCC) based on high‐risk pathologic features, smoking, and outcomes using The Cancer Microbiome Atlas (TCMA). Study Design Database study. Setting Database review.
Delaney H. Sheehan, Kesava Asam, Nicolaus D. Knight, Juhi J. Patel, James A. Stewart, Patrick A. Molina, Nengjun Yi, Chi T. Viet, Brad Aouizerat, Natalie Silver, Bharat Panuganti, Carissa M. Thomas   +11 more
wiley   +1 more source

Protein Tyrosine Phosphatase Non-Receptor Type 2 Regulates NLRP3 Inflammasome Activation

, 2011
Helen M. Becker, Barbara Schnell, Joba M. Arikkat, Markus Schuppler, Martin J. Loessner, Michael Fried, Gerhard Rogler, Michael Scharl   +7 more
openalex   +1 more source

Fenofibrate mitigates the dysfunction of high glucose-driven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome. [PDF]

Int J Ophthalmol
Shi Y, Chen HM, Liu AH, Li XR.
europepmc   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

The Journal of Pathology, EarlyView.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk, Guolu Tang, Arno R Bourgonje, Wilfred FA den Dunnen, Jan‐Luuk Hillebrands, Harry van Goor   +5 more
wiley   +1 more source

Inhibition of NLRP3 Inflammasome Signaling Confers Susceptibility to Intestinal Inflammation Through Dysregulation of IL-15 Expression

, 2011
Simon A. Hirota, Mireille S. Potentier, Aito Ueno, Jeffrey Ng, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck   +8 more
openalex   +1 more source