Results 261 to 270 of about 135,870 (288)

FA-2-b-β modulates HMGB1/NF-κB/NLRP3 signaling to alleviate neuroinflammation in Alzheimer's disease. [PDF]

J Alzheimers Dis
Zhang Y, Wang J, Yuan J, Li S, Sun Y.
europepmc   +1 more source

Association of NLRP3 (rs4612666) polymorphism in gingival crevicular fluid with symptomatic irreversible pulpitis and asymptomatic apical periodontitis. [PDF]

J Oral Biol Craniofac Res
Verma S, Abraham D, Sharma V, Goyal A, Gupta A, Jala S, Singh G, Malhotra RK.   +7 more
europepmc   +1 more source

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NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages

International Immunopharmacology, 2021
INF39 is a nontoxic, irreversible, acrylate-based NLRP3 inhibitor and a further optimization of ethyl 2-((2-chlorophenyl) hydroxyl) methyl) acrylate (INF4E). However, the detail mechanism and the direct target of its anti-inflammatory activity is not clear. Here, we show that INF39 is a specific inhibitor for NLRP3 inflammasome activation.
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi   +4 more
openaire   +2 more sources

Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

International Immunopharmacology, 2023
NLR family pyrin domain-containing 3 (NLRP3)-mediated pyroptosis plays a key role in various acute and chronic inflammatory diseases. Targeted inhibition of NLRP3-mediated pyroptosis may be a potential therapeutic strategy for various inflammatory diseases.
Miao Ren, Jiahao Chen, Haowen Xu, Weifeng Li, Tingting Wang, Zhanghuan Chi, Yi Lin, Anqi Zhang, Gaozhi Chen, Xu Wang, Xiaoyu Sun, Guang Liang, Junlu Wang, Wu Luo   +13 more
openaire   +2 more sources