Results 281 to 288 of about 135,870 (288)

Tyrosine Phosphorylation of NLRP3 by Lyn Suppresses NLRP3 Inflammasome Activation

The Journal of Immunology, 2017
Abstract The NLRP3 inflammasome is a multi-protein complex that triggers the activation of inflammatory caspase-1 and the maturation of IL-1β and IL-18 in response to microbes and danger signals in the cytosol of host cells. However, how the NLRP3 inflammasome is regulated is not well defined.
Guoxin Lin, Juan Tang, Hui Guo, Yun Xiao, Neetu Gupta, Na Tang, Jian Zhang   +6 more
openaire   +1 more source

The Nlrp3 inflammasome admits defeat

Trends in Immunology, 2015
The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
openaire   +2 more sources

NEK7 activates NLRP3

Science Signaling, 2016
A kinase that mediates mitosis is required for activation of the NLRP3 inflammasome.
openaire   +1 more source

NLRP3 moonlights in TH2 polarization

Nature Immunology, 2015
As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization.
Jenny P Y Ting, Jonathan A Harton
openaire   +2 more sources

Bile acids block NLRP3

Nature Immunology, 2016
openaire   +2 more sources

NLRP3 inflammasomi

2023
openaire   +1 more source

FNTA facilitates NLRP3 inflammasome activation by enhancing NLRP3 stability

SCIENTIA SINICA Vitae
Liqiu Wang, Jun Cui
openaire   +1 more source

Dopamine controls NLRP3

Nature Immunology, 2015
openaire   +1 more source