Results 281 to 290 of about 135,752 (336)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Antidepressant-Like Effects of Electroacupuncture by Regulating NLRP3-mediated Hippocampal Inflammation and Pyroptosis in Rats With Post-Stroke Depression. [PDF]

Brain Behav
Cai W, Wei XF, Tao L, Shen WD.
europepmc   +1 more source

Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice

, 2012
Sheri L. Bonar, Susannah Brydges, James L. Mueller, Matthew D. McGeough, Carla A. Peña, Debbie Chen, Susan K. Grimston, Cynthia L. Hickman‐Brecks, Soumya Ravindran, Audrey McAlinden, Deborah V. Novack, Daniel L. Kastner, Roberto Civitelli, Hal M. Hoffman, Gabriel Mbalaviele   +14 more
openalex   +2 more sources

Role of TREM1 in the sevoflurane‐induced inflammatory activation of microglia in vitro

Ibrain, EarlyView.
Perioperative neurocognitive disorders (PNDs) are one of the most common complications in perioperative patients, and neuroinflammatory reaction mediated by microglia plays a key role in their formation. Triggering receptor expressed on myeloid cells 1 (TREM1) is a key regulator of inflammation.
Chunchun Tang, Yuhang Zhu, Dexing Liu, Xue Zheng, Junli Jiang, Wanqiu Yu, Yinan Zhang, Dongqin Chen, Zhaoqiong Zhu   +8 more
wiley   +1 more source

NLRP3 Inflammasome Activation in Liver Disorders: From Molecular Pathways to Therapeutic Strategies. [PDF]

J Inflamm Res
Ma W, Wang Y, Liu J.
europepmc   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Danshensu Ethyl Ester Alleviates LPS-Induced Acute Lung Injury by Targeting the NLRP3 Inflammasome. [PDF]

J Inflamm Res
Ding W, Xu S, Xie S, Dong Y, Jiang Y, Xie N, Wang P, Feng J, Qu G.   +8 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

NLRP3 inflammasome-driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors. [PDF]

Sci Adv
Shojaee F, Azadian E, Wong MX, Ma X, Rickard J, Pang J, Hall C, Kueh AJ, Masters SL, Rioja I, Prinjha RK, Doerflinger M, Lawlor KE, Rashidi M, Vince JE.   +14 more
europepmc   +1 more source

The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1β Production and Activates the NLRP3 Inflammasome in Human Macrophages

, 2012
Tsung‐Teng Huang, David M. Ojcius, John Ding‐E Young, Yihui Wu, Yun‐Fei Ko, Tsui-Yin Wong, Cheng-Yeu Wu, Chia‐Chen Lu, Hsin‐Chih Lai   +8 more
openalex   +2 more sources