Results 31 to 40 of about 106,369 (300)

Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation [PDF]

arXiv, 2023
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles.
arxiv  

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Experimental and Molecular Medicine, 2022
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang, Gaocai Li, Rongjin Luo, J. Lei, Yu Song, Bingjin Wang, Liang Ma, Zhiwei Liao, Wencan Ke, Hui Liu, Wenbin Hua, K. Zhao, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang   +16 more
semanticscholar   +1 more source

Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease

Journal of Inflammation Research, 2021
Ran Zheng, Yang Ruan, Yiqun Yan, Zhihao Lin, Naijia Xue, Yaping Yan, Jun Tian, Xinzhen Yin, Jiali Pu, Baorong Zhang Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, 310009, People’s Republic of ...
Zheng R, Ruan Y, Yan Y, Lin Z, Xue N, Yan Y, Tian J, Yin X, Pu J, Zhang B   +9 more
doaj  

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Nature Immunology, 2022
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including ...
L. Billingham, J. Stoolman, Karthik Vasan, Arianne E. Rodriguez, T. Poor, M. Szibor, H. Jacobs, Colleen R. Reczek, Aida Rashidi, P. Zhang, J. Miska, N. Chandel   +11 more
semanticscholar   +1 more source

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

Nature, 2022
NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis1,2. The conformational states of NLRP3 and the way antagonistic small molecules act at the
Inga V. Hochheiser, M. Pilsl, G. Hagelueken, Jonas Moecking, M. Marleaux, Rebecca Brinkschulte, E. Latz, C. Engel, M. Geyer   +8 more
semanticscholar   +1 more source

Investigation the reasons for varying the severity of COVID-19 from person to person: A review study

Fiyz̤, 2022
Background: COVID-19 is caused by the SARS-COV-2 virus and mainly affects the lung tissue. In addition, other tissues are attacked by the virus. Reports have shown that clinical manifestations in Covid-19 patients vary from asymptomatic to acute ...
Mohsen Rahmani, Bahare Nikoozar , Mahboobeh Golchin, Marziyeh Tavalaee , Mehdi Hajian , Mohammad Hossein Nasr-Esfahani   +5 more
doaj  

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1

Journal of Immunology, 2009
The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine receptors control pro-IL-1β transcription whereas inflammasomes regulate the proteolytic processing of pro-IL-1β.
F. Bauernfeind, Gabor L Horvath, A. Stutz, E. Alnemri, K. MacDonald, D. Speert, T. Fernandes‐Alnemri, Jianghong Wu, Brian G. Monks, K. Fitzgerald, V. Hornung, E. Latz   +11 more
semanticscholar   +1 more source

The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes

Journal of Inflammation Research, 2022
Lei Zhang,1,* Huan-Huan Liu,2,* Feng Li,1 Fan Yang,1 Ling-Ling Qian,1 Ru-Xing Wang1 1Department of Cardiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, People’s Republic of China; 2Wuxi School of Medicine, Jiangnan ...
Zhang L, Liu HH, Li F, Yang F, Qian LL, Wang RX   +5 more
doaj  

Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception

Journal of Inflammation Research, 2020
Haiyan Wang1 ,* Yu Zhang1 ,* Xiaqing Ma,1 Wenying Wang,1 Xiaotao Xu,1 Min Huang,1 Liang Xu,2 Haibo Shi,3 Tifei Yuan,4 Wei Jiang,1 Aizhong Wang,1 Tao Xu1,5 1Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People’s ...
Wang H, Zhang Y, Ma X, Wang W, Xu X, Huang M, Xu L, Shi H, Yuan T, Jiang W, Wang A, Xu T   +11 more
doaj  

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

Drug Design, Development and Therapy, 2022
Muhammad Riaz,1 Lina Tariq Al Kury,2 Noreen Atzaz,3 Abdullah Alattar,4 Reem Alshaman,4 Fawad ali Shah,1 Shupeng Li5 1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan; 2Department of Natural and Health ...
Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S   +6 more
doaj